Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8521, USA.
J Mol Cell Cardiol. 2013 Feb;55:12-8. doi: 10.1016/j.yjmcc.2012.08.025. Epub 2012 Sep 7.
There is a long history of investigation into the metabolism of the failing heart. Congestive heart failure is marked both by severe disruptions in myocardial energy supply and an inability of the heart to efficiently uptake and oxidize fuels. Despite the many advancements in our understanding, there are still even more outstanding questions in the field. Metabolomics has the power to assist our understanding of the metabolic derangements which accompany myocardial dysfunction. Metabolomic investigations in animal models of heart failure have already highlighted several novel, potentially important pathways of substrate selection and toxicity. Metabolomic biomarker studies in humans, already successfully applied to other forms of cardiovascular disease, have the potential to improve diagnosis and patient care. This article is part of a Special Issue entitled "Focus on Cardiac Metabolism".
对衰竭心脏的代谢研究由来已久。充血性心力衰竭的特点是心肌能量供应严重紊乱，以及心脏无法有效摄取和氧化燃料。尽管我们对这方面的了解有了很大的进步，但该领域仍有更多悬而未决的问题。代谢组学有助于我们理解伴随心肌功能障碍的代谢紊乱。心力衰竭动物模型的代谢组学研究已经强调了几种新的、潜在重要的底物选择和毒性途径。代谢组学生物标志物研究已经成功应用于其他形式的心血管疾病，有可能改善诊断和患者护理。本文是特刊“关注心脏代谢”的一部分。
