功能磁共振成像在药物研发中的作用。
The role of fMRI in drug development.
机构信息
Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Eli Lilly and Company, Indianapolis, IN, USA.
出版信息
Drug Discov Today. 2018 Feb;23(2):333-348. doi: 10.1016/j.drudis.2017.11.012. Epub 2017 Nov 15.
Abstract
Functional magnetic resonance imaging (fMRI) has been known for over a decade to have the potential to greatly enhance the process of developing novel therapeutic drugs for prevalent health conditions. However, the use of fMRI in drug development continues to be relatively limited because of a variety of technical, biological, and strategic barriers that continue to limit progress. Here, we briefly review the roles that fMRI can have in the drug development process and the requirements it must meet to be useful in this setting. We then provide an update on our current understanding of the strengths and limitations of fMRI as a tool for drug developers and recommend activities to enhance its utility.
摘要
功能性磁共振成像（fMRI）十多年来一直被认为具有极大的潜力，可以极大地促进开发治疗常见健康状况的新型治疗药物的进程。然而，由于各种技术、生物和战略障碍继续限制进展，fMRI 在药物开发中的应用仍然相对有限。在这里，我们简要回顾 fMRI 在药物开发过程中可以发挥的作用，以及它在这种情况下必须满足的要求。然后，我们提供了当前对 fMRI 作为药物开发人员工具的优势和局限性的理解的更新，并建议了增强其效用的活动。
相似文献
1
The role of fMRI in drug development.功能磁共振成像在药物研发中的作用。
Drug Discov Today. 2018 Feb;23(2):333-348. doi: 10.1016/j.drudis.2017.11.012. Epub 2017 Nov 15.
2
Machine learning in chemoinformatics and drug discovery.机器学习在化学生信学和药物发现中的应用。
Drug Discov Today. 2018 Aug;23(8):1538-1546. doi: 10.1016/j.drudis.2018.05.010. Epub 2018 May 8.
3
Mechanistic applications of click chemistry for pharmaceutical drug discovery and drug delivery.点击化学在药物发现和药物输送中的机制应用。
Drug Discov Today. 2017 Nov;22(11):1604-1619. doi: 10.1016/j.drudis.2017.07.007. Epub 2017 Jul 25.
4
Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?在药物化学的 hit 和 lead 优化过程中呈现的药物相似性过滤器：它们可以简化到什么程度？
Drug Discov Today. 2018 Mar;23(3):605-615. doi: 10.1016/j.drudis.2018.01.010. Epub 2018 Jan 9.
5
The application of absolute quantitative (1)H NMR spectroscopy in drug discovery and development.绝对定量 (1)H NMR 光谱学在药物发现和开发中的应用。
Expert Opin Drug Discov. 2016 Jul;11(7):695-706. doi: 10.1080/17460441.2016.1189899. Epub 2016 Jun 3.
6
Functional Magnetic Resonance Imaging Studies in Sexual Medicine: A Primer.性功能障碍磁共振成像研究：入门篇
J Sex Med. 2022 Jul;19(7):1073-1089. doi: 10.1016/j.jsxm.2022.03.217. Epub 2022 Apr 11.
7
Overview of determination of biopharmaceutical properties for development candidate selection.用于开发候选药物筛选的生物制药特性测定概述。
Curr Protoc Pharmacol. 2013 Mar;Chapter 9:Unit9.17. doi: 10.1002/0471141755.ph0917s60.
8
Capillary electrophoresis and small molecule drug discovery: a perfect match?毛细管电泳与小分子药物发现：天作之合？
Drug Discov Today. 2012 Apr;17(7-8):396-404. doi: 10.1016/j.drudis.2012.02.008. Epub 2012 Feb 23.
9
A Special Section on Pharmaceutical Nanotechnology: Development of Soft Nanoparticles and Their Biological Evaluations.药物纳米技术专题：软纳米颗粒的开发及其生物学评价
J Nanosci Nanotechnol. 2016 Feb;16(2):1235-7. doi: 10.1166/jnn.2016.11664.
10
Approaches for high-throughput pharmacokinetic screening of low-molecular-weight drug candidates.低分子量候选药物高通量药代动力学筛选方法。
Expert Opin Drug Metab Toxicol. 2014 Feb;10(2):139-42. doi: 10.1517/17425255.2014.870153. Epub 2013 Dec 13.
引用本文的文献
1
Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations.神经递质活性的药理学操纵对脑血流量和静息态波动产生不同的影响。
Imaging Neurosci (Camb). 2024 Nov 20;2. doi: 10.1162/imag_a_00370. eCollection 2024.
2
Resting-state functional magnetic resonance imaging in a randomized clinical trial for Alzheimer's disease.阿尔茨海默病随机临床试验中的静息态功能磁共振成像
Neuroimage Rep. 2021 Sep 24;1(4):100055. doi: 10.1016/j.ynirp.2021.100055. eCollection 2021 Dec.
3
Re-evaluating our focus in addiction: emotional dysregulation is a critical driver of relapse to drug use.重新评估我们在成瘾问题上的关注点：情绪失调是导致药物使用复发的关键驱动因素。
Transl Psychiatry. 2024 Nov 9;14(1):467. doi: 10.1038/s41398-024-03159-5.
4
Neuroimaging Biomarkers in Addiction.成瘾中的神经影像学生物标志物
medRxiv. 2024 Sep 3:2024.09.02.24312084. doi: 10.1101/2024.09.02.24312084.
5
Can we achieve pain stratification in musculoskeletal conditions? Implications for clinical practice.我们能否在肌肉骨骼疾病中实现疼痛分层？对临床实践的启示。
Front Pain Res (Lausanne). 2024 Mar 7;5:1362757. doi: 10.3389/fpain.2024.1362757. eCollection 2024.
6
Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity: A Systematic Review.25 年 fMRI 药物线索反应性研究中的参数空间和生物标志物开发潜力：系统综述。
JAMA Psychiatry. 2024 Apr 1;81(4):414-425. doi: 10.1001/jamapsychiatry.2023.5483.
7
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments.在大脑和电刺激之间形成闭环：走向精确的神经调节治疗。
Transl Psychiatry. 2023 Aug 14;13(1):279. doi: 10.1038/s41398-023-02565-5.
8
Review: The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression.综述：功能磁共振成像（fMRI）在抑郁症临床试验和实验研究中的应用。
Front Neuroimaging. 2023 Jun 27;2:1110258. doi: 10.3389/fnimg.2023.1110258. eCollection 2023.
9
Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles.临床前药理研究背景下的磁共振成像和超声弹性成像：对3R原则的意义
Front Pharmacol. 2023 Jun 28;14:1177421. doi: 10.3389/fphar.2023.1177421. eCollection 2023.
10
Experimental Medicine Approaches in Early-Phase CNS Drug Development.中枢神经系统药物早期研发中的实验医学方法
Adv Neurobiol. 2023;30:417-455. doi: 10.1007/978-3-031-21054-9_17.
本文引用的文献
1
A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process.翻译：翻译：对疼痛和镇痛中转译成像的有效性和实用性的批判性评价：利用功能成像来增强这一过程。
Neurosci Biobehav Rev. 2018 Jan;84:407-423. doi: 10.1016/j.neubiorev.2017.08.004. Epub 2017 Aug 12.
2
Best practices in data analysis and sharing in neuroimaging using MRI.使用磁共振成像（MRI）进行神经成像数据分析与共享的最佳实践。
Nat Neurosci. 2017 Feb 23;20(3):299-303. doi: 10.1038/nn.4500.
3
Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.转化药理学研究中静息态功能磁共振成像的生物标志物、设计与解读：脑化学研究的现状、挑战与机遇综述
Hum Brain Mapp. 2017 Apr;38(4):2276-2325. doi: 10.1002/hbm.23516. Epub 2017 Feb 1.
4
Imaging in Central Nervous System Drug Discovery.中枢神经系统药物研发中的影像学
Semin Nucl Med. 2017 Jan;47(1):89-98. doi: 10.1053/j.semnuclmed.2016.09.001. Epub 2016 Oct 28.
5
Fast Bayesian whole-brain fMRI analysis with spatial 3D priors.具有空间3D先验的快速贝叶斯全脑功能磁共振成像分析。
Neuroimage. 2017 Feb 1;146:211-225. doi: 10.1016/j.neuroimage.2016.11.040. Epub 2016 Nov 19.
6
Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats.与压后皮质的功能连接可预测大鼠的认知衰老。
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12286-12291. doi: 10.1073/pnas.1525309113. Epub 2016 Oct 10.
7
Pharmaco fMRI: Determining the functional anatomy of the effects of medication.药物功能磁共振成像：确定药物作用的功能解剖学
Neuroimage Clin. 2016 Oct 4;12:691-697. doi: 10.1016/j.nicl.2016.10.002. eCollection 2016.
8
Brain imaging of pain: state of the art.疼痛的脑成像：最新进展
J Pain Res. 2016 Sep 8;9:613-24. doi: 10.2147/JPR.S60433. eCollection 2016.
9
Constituents and functional implications of the rat default mode network.大鼠默认模式网络的组成成分及其功能意义。
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4541-7. doi: 10.1073/pnas.1601485113. Epub 2016 Jul 20.
10
Functional atlas of the awake rat brain: A neuroimaging study of rat brain specialization and integration.清醒大鼠脑的功能图谱：大鼠脑特化和整合的神经影像学研究。
Neuroimage. 2018 Apr 15;170:95-112. doi: 10.1016/j.neuroimage.2016.07.007. Epub 2016 Jul 5.
Zotero 插件