Yoshida J, Polley E H, Nyhus L M, Donahue P E
Department of Surgery, University of Illinois College of Medicine, Chicago.
J Surg Res. 1989 Jan;46(1):60-9. doi: 10.1016/0022-4804(89)90182-0.
If preganglionic vagus nerve fibers enter the stomach via all of its neurovascular bundles, then proximal gastric vagotomy that divides only the bundles along the lesser curvature of the stomach neglects a potential source of innervation to the parietal cells. To determine whether or not these bundles contained preganglionic efferent vagal nerve fibers, horseradish peroxidase was applied to the central cut end of selected neurovascular bundles along the greater curvature of the stomach in rats and ferrets. Cells in the dorsal motor nucleus of the vagus (dmnX) of the rat were labeled after horseradish peroxidase applications to the right gastroepiploic, the splenic, and the short gastric bundles. The ferrets had horseradish peroxidase applied to the right gastroepiploic bundle and they also had cellular labeling of the dmnX. The labeling in cells of the dorsal motor nucleus of the vagus had a distinct topographic, rostrocaudal distribution in both species, and was maximal in the vicinity of the obex. Cells of the bilateral dmnX were labeled after horseradish peroxidase applications at all bundles. This study showed (1) that the bundles along the greater curvature of the stomach contained preganglionic efferent vagus nerve fibers, (2) that the cells of origin of these fibers were represented in the localized rostrocaudal position of the dmnX, and (3) that these fibers had their origins in the bilateral dmnX. Such nerve fibers may account for incomplete vagal denervation of the parietal cells after proximal gastric vagotomy.
如果节前迷走神经纤维通过胃的所有神经血管束进入胃，那么仅切断沿胃小弯的神经血管束的近端胃迷走神经切断术就忽略了壁细胞潜在的神经支配来源。为了确定这些神经血管束中是否含有节前传出迷走神经纤维，将辣根过氧化物酶应用于大鼠和雪貂胃大弯处选定神经血管束的中央切断端。将辣根过氧化物酶应用于大鼠的右胃网膜束、脾束和胃短束后，迷走神经背运动核（dmnX）中的细胞被标记。给雪貂的右胃网膜束应用辣根过氧化物酶后也出现了dmnX的细胞标记。在这两个物种中，迷走神经背运动核细胞中的标记都有明显的前后分布，在闩附近最为明显。在所有神经血管束应用辣根过氧化物酶后，双侧dmnX的细胞都被标记。这项研究表明：（1）沿胃大弯的神经血管束含有节前传出迷走神经纤维；（2）这些纤维的起源细胞在dmnX的局部前后位置有体现；（3）这些纤维起源于双侧dmnX。这类神经纤维可能是近端胃迷走神经切断术后壁细胞迷走神经去神经支配不完全的原因。
