Donahue P E, Yoshida J, Polley E H, Nyhus L M
Department of Surgery, University of Illinois at Chicago.
Gastroenterology. 1988 Jun;94(6):1292-9. doi: 10.1016/0016-5085(88)90666-x.
The efferent gastric vagus nerve fibers appear to enter the stomach by several routes. For example, the rate of gastric acid secretion is directly affected by the nerves of the greater curvature of the stomach. Specifically, acid secretion decreases abruptly after division of the gastroepiploic nerve(s). To determine whether efferent vagus nerve fibers are contained in the gastroepiploic nerve(s), horseradish peroxidase, a protein that undergoes retrograde axonal transport, was applied to these nerves; the brainstem locus of the nuclei of the vagus nerves was examined 2 days later. Typical peroxidase labeling was observed in the dorsal motor nucleus of the vagus nerve in 5 of 6 rats and 3 of 3 ferrets; the hypothesis that efferent vagus nerves enter the greater curvature of the stomach was thus supported in two vertebrate species. These previously unrecognized nerves should be considered in the interpretation of experimental and clinical phenomena.
传出性胃迷走神经纤维似乎通过多种途径进入胃。例如，胃酸分泌速率直接受胃大弯神经的影响。具体而言，胃网膜神经切断后胃酸分泌会突然减少。为了确定胃网膜神经中是否含有传出性迷走神经纤维，将辣根过氧化物酶（一种可进行逆行轴突运输的蛋白质）应用于这些神经；两天后检查迷走神经核在脑干中的位置。在6只大鼠中的5只以及3只雪貂中的3只的迷走神经背运动核中观察到了典型的过氧化物酶标记；因此，在两种脊椎动物中支持了传出性迷走神经进入胃大弯的假说。在解释实验和临床现象时应考虑这些先前未被认识的神经。
