Christensen Anne Friesgaard, Sorensen Grith Lykke, Junker Kirsten, Revald Peter Hvidbak, Varnum Claus, Sorensen Flemming Brandt, Junker Peter
Department of Internal Medicine, Lillebaelt Hospital, Vejle, Denmark.
Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
APMIS. 2018 Jan;126(1):9-13. doi: 10.1111/apm.12785. Epub 2017 Nov 20.
Surfactant protein-D (SP-D) is a collectin, which plays an important role in airway protection and inflammation. The molecule has both pro- and anti-inflammatory capacities depending on its molecular size. Its involvement in joint diseases is largely unknown and the aim of this investigation was to study SP-D occurrence and distribution in the synovial membrane of patients with long-standing rheumatoid arthritis (RA) and osteoarthritis (OA). Six RA patients and six OA patients, who underwent total hip arthroplasty, were included in the study. Synovial tissue biopsies were obtained during surgery and subsequently prepared for immunohistochemistry. In this first, small-scale comparative study on the occurrence of SP-D in the synovial membrane of RA and OA, we report that SP-D was only present in the microvascular endothelium in subsynovial and pannus tissue and that the immunostaining was much stronger than in OA. This distribution pattern suggests that SP-D modulates RA inflammatory activities.
表面活性蛋白-D（SP-D）是一种凝集素，在气道保护和炎症中发挥重要作用。该分子根据其分子大小具有促炎和抗炎能力。其在关节疾病中的作用在很大程度上尚不清楚，本研究的目的是研究SP-D在长期类风湿性关节炎（RA）和骨关节炎（OA）患者滑膜中的存在情况和分布。本研究纳入了6例接受全髋关节置换术的RA患者和6例OA患者。在手术过程中获取滑膜组织活检样本，随后进行免疫组织化学制备。在这项关于RA和OA滑膜中SP-D存在情况的首次小规模比较研究中，我们报告SP-D仅存在于滑膜下层和血管翳组织的微血管内皮中，且免疫染色比OA中强得多。这种分布模式表明SP-D调节RA的炎症活动。
