Shakya Akhilesh Kumar, Kandalam Umadevi
Department of Chemical Engineering, Texas Tech University, Lubbock, TX, USA.
Department of Paediatric Dentistry, Nova Southeastern University, Fort Lauderdale, Florida.
Br J Oral Maxillofac Surg. 2017 Nov;55(9):875-891. doi: 10.1016/j.bjoms.2017.09.007. Epub 2017 Oct 19.
Repair of critical-size defects caused by trauma, removal of a tumour, or congenital abnormalities is a challenge in the craniomaxillofacial region because of the limitations associated with treatment. We have reviewed research papers and updated information relevant to the various types of macroporous scaffolds. We have included papers on several biomaterials and their use in various craniofacial defects such as mandibular, calvarial, and others, as well as the latest technological developments such as 3-dimensional printed scaffolds. We selected all papers about scaffolds, stem cells, and growth factors for review. Initial selection was by review of titles and abstracts, and the full texts of potentially suitable articles were then assessed. Methods of tissue engineering for repair of critical-size defects in the craniofacial bones seem to be viable options for surgical treatment in the future. Macroporous scaffolds with interconnected pores are of great value in regeneration of bone in the craniofacial region. In recent years, various natural or synthetic materials, or both, have been developed, on which macroporous scaffolds can be based. In this review we present a review on the various types of three-dimensional macroporous scaffolds that have been developed in recent years, and evaluate their potential for regeneration of craniofacial bone.
由于治疗存在局限性，修复由创伤、肿瘤切除或先天性异常引起的颅颌面区域临界尺寸骨缺损是一项挑战。我们回顾了与各种类型大孔支架相关的研究论文和最新信息。我们纳入了关于几种生物材料及其在各种颅面缺损（如下颌骨、颅骨等）中的应用的论文，以及诸如三维打印支架等最新技术进展。我们挑选了所有关于支架、干细胞和生长因子的论文进行综述。最初通过标题和摘要进行筛选，然后对潜在合适文章的全文进行评估。颅面骨临界尺寸缺损修复的组织工程方法似乎是未来手术治疗的可行选择。具有相互连通孔隙的大孔支架在颅面区域骨再生中具有重要价值。近年来，已开发出各种天然或合成材料，或两者兼具，可作为大孔支架的基础。在本综述中，我们对近年来开发的各种类型三维大孔支架进行综述，并评估它们在颅面骨再生方面的潜力。
