Oliver Jeremie D, Madhoun Wasila, Graham Emily M, Hendrycks Russell, Renouard Maranda, Hu Michael S
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
School of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USA.
J Clin Med. 2020 Oct 15;9(10):3307. doi: 10.3390/jcm9103307.
The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region.
颅面部区域包含人体中最复杂和精细的解剖结构。由于发育缺陷、创伤性损伤或肿瘤组织形成，面部和颅骨的功能及美学复杂性常常遭到破坏。尽管该领域长期以来一直在创新重建技术，但颅颌面形态和功能的手术修复仍存在关键局限性。幸运的是，再生医学与手术的兴起为患有软硬组织缺损的患者拓展了可能性，能够实现针对患者特定缺损的可控工程化和再生。特别是，干细胞疗法近年来已成为颅颌面结构靶向再生的辅助治疗方法。本综述概述了用于颅面部区域骨骼缺损的工程化修复和再生的干细胞疗法的当前技术水平。
