在食管鳞状细胞癌进展过程中，HOTAIR通过与内源性miR - 125和miR - 143结合来调节HK2的表达。
HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression.
作者信息
Ma Jian, Fan Yanxin, Feng Tingting, Chen Fangjun, Xu Zhipeng, Li Suqing, Lin Qingfeng, He Xiaoting, Shi Weihong, Liu Yang, Liu Zhihua, Zhu Bin, Cao Xiufeng
机构信息
Department of Surgical Oncology, Affiliated Nanjing First Hospital of Nanjing Medical University, Oncology Center of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.
Jiangsu Cancer Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China.
出版信息
Oncotarget. 2017 Sep 23;8(49):86410-86422. doi: 10.18632/oncotarget.21195. eCollection 2017 Oct 17.
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The "competitive endogenous RNA" (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy.
食管鳞状细胞癌（ESCC）是全球最常见的恶性肿瘤之一，死亡率很高。长链非编码RNA（LncRNA）最近已被证明在ESCC中起关键作用。LncRNA HOTAIR在ESCC中发挥重要的调控作用。我们着重介绍了HOTAIR通过直接结合miR-125和miR-143影响ESCC中己糖激酶2（HK2）表达的分子机制。综上所述，本研究确定了一种功能性lncRNA HOTAIR，它通过miRNA-125/miRNA-143-HK2参与ESCC细胞糖酵解的调控。HOTAIR/miR-125和miR143/HK2相互作用的“竞争性内源RNA”（ceRNA）模型可能成为ESCC诊断和治疗的重要靶点。
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