Pfankuche Vanessa M, Jo Wendy K, van der Vries Erhard, Jungwirth Nicole, Lorenzen Stephan, Osterhaus Albert D M E, Baumgärtner Wolfgang, Puff Christina
1 Department of Pathology, University of Veterinary Medicine, Hannover, Germany.
2 Center for Systems Neuroscience, Hannover, Germany.
Vet Pathol. 2018 Mar;55(2):294-297. doi: 10.1177/0300985817738096. Epub 2017 Nov 20.
Feline panleukopenia virus (FPV) infections are typically associated with anorexia, vomiting, diarrhea, neutropenia, and lymphopenia. In cases of late prenatal or early neonatal infections, cerebellar hypoplasia is reported in kittens. In addition, single cases of encephalitis are described. FPV replication was recently identified in neurons, although it is mainly found in cells with high mitotic activity. A female cat, 2 months old, was submitted to necropsy after it died with neurologic deficits. Besides typical FPV intestinal tract changes, multifocal, randomly distributed intracytoplasmic vacuoles within neurons of the thoracic spinal cord were found histologically. Next-generation sequencing identified FPV-specific sequences within the central nervous system. FPV antigen was detected within central nervous system cells, including the vacuolated neurons, via immunohistochemistry. In situ hybridization confirmed the presence of FPV DNA within the vacuolated neurons. Thus, FPV should be considered a cause for neuronal vacuolization in cats presenting with ataxia.
猫泛白细胞减少症病毒（FPV）感染通常与厌食、呕吐、腹泻、中性粒细胞减少和淋巴细胞减少有关。在产前晚期或新生儿早期感染的病例中，有报道称小猫会出现小脑发育不全。此外，还描述了个别脑炎病例。尽管FPV主要在有高有丝分裂活性的细胞中发现，但最近在神经元中也发现了其复制情况。一只2个月大的母猫在死于神经功能缺损后进行了尸检。除了典型的FPV肠道变化外，组织学检查发现胸段脊髓神经元内有多处随机分布的胞浆内空泡。下一代测序在中枢神经系统中鉴定出了FPV特异性序列。通过免疫组织化学在中枢神经系统细胞内检测到了FPV抗原，包括空泡化神经元。原位杂交证实了空泡化神经元内存在FPV DNA。因此，对于出现共济失调的猫，FPV应被视为神经元空泡化的一个病因。
