Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, 6-3-7, Minatojimaminami-machi, Chuo-ku, Kobe, 650-0047, Japan.
Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Int J Hematol. 2023 Jun;117(6):821-829. doi: 10.1007/s12185-023-03587-x. Epub 2023 Apr 12.
Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.
造血是由骨髓中一种称为龛的特定微环境维持和调节的。在血液系统恶性肿瘤中，肿瘤细胞诱导龛的重塑，而重建的龛与疾病的发病机制密切相关。最近的研究表明，肿瘤细胞分泌的细胞外囊泡（EVs）在血液系统恶性肿瘤中龛的重塑中起主要作用。尽管 EVs 作为潜在的治疗靶点正在出现，但作用机制尚不清楚，选择性抑制仍然是一个挑战。本文综述了血液系统恶性肿瘤中骨髓微环境的重塑及其对发病机制的贡献，以及肿瘤衍生 EVs 的作用，并对该领域的未来研究提供了展望。
