Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Department of Urology, Shanghai Six People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Sci Rep. 2017 Nov 20;7(1):15874. doi: 10.1038/s41598-017-16108-8.
Previous studies have reported that insulin resistant and low testosterone are related. The triglyceride and glucose index (TyG) well mirrors insulin sensitivity. No study investigated the application of TyG in male hypogonadism. We aimed to explore whether TyG was associated with hypogonadism, and also evaluate the ability of TyG compared to HOMA-IR as a possible hypogonadism predictor. A total of 4299 male subjects were enrolled from 22 sites in East China. Hypogonadism was defined as total testosterone <11.3 nmol/L. 695 (16.2%) hypogonadal men had significantly higher TyG index. The prevalence of hypogonadism stepwise increased across increasing TyG quartiles (P < 0.01). TyG was negatively associated with sex hormones and hypogonadism after adjustment for age, current smoking status, hypertension and overweight/obesity (all P for trend <0.01). The full-adjusted odds ratio was 6.1 for the highest quartile compared with the lowest quartile of TyG (95% CI 4.51, 8.25, P < 0.001). On ROC curve analysis, a larger area under the curve was found for TyG (0.71, 95% CI 0.69,0.73) than for HOMA-IR (0.68, 95% CI 0.66,0.70). Thus, the TyG was significantly associated with a higher prevalence of hypogonadism in Chinese men. TyG had a better predictive power for hypogonadism than HOMA-IR.
先前的研究报告指出，胰岛素抵抗与低睾酮有关。甘油三酯和葡萄糖指数（TyG）很好地反映了胰岛素敏感性。目前尚无研究探讨 TyG 在男性性腺功能减退症中的应用。我们旨在探讨 TyG 是否与性腺功能减退症有关，并评估 TyG 作为可能的性腺功能减退症预测因子的能力，与 HOMA-IR 相比。共纳入来自华东 22 个中心的 4299 名男性受试者。性腺功能减退症定义为总睾酮<11.3 nmol/L。695 名（16.2%）性腺功能减退症男性的 TyG 指数显著较高。随着 TyG 四分位数的增加，性腺功能减退症的患病率逐渐增加（P<0.01）。在调整年龄、当前吸烟状况、高血压和超重/肥胖后，TyG 与性激素和性腺功能减退症呈负相关（所有趋势 P 值均<0.01）。与 TyG 最低四分位数相比，最高四分位数的全调整比值比为 6.1（95%CI 4.51，8.25，P<0.001）。在 ROC 曲线分析中，TyG 的曲线下面积较大（0.71，95%CI 0.69，0.73），高于 HOMA-IR（0.68，95%CI 0.66，0.70）。因此，TyG 与中国男性性腺功能减退症的高患病率显著相关。TyG 对性腺功能减退症的预测能力优于 HOMA-IR。
