Department of Health Promotion Center, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Lipids Health Dis. 2020 Oct 7;19(1):218. doi: 10.1186/s12944-020-01393-6.
The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD.
A total of 4784 participants who underwent ultrasonography were enrolled. Anthropometric and biochemical measurements were assessed. Participants with NAFLD were diagnosed by ultrasound. The degree of hepatic steatosis and liver stiffness was evaluated with transient elastography.
The TyG index was significantly correlated with the severity of hepatic steatosis and the presence of liver fibrosis in patients with NAFLD. TyG quartile values correlated with increasing prevalence of NAFLD (Q1 30.9%, Q2 53.3%, Q3 71.7%, and Q4 86.4%, P < 0.001) and with the presence of liver fibrosis (Q1 13.5%, Q2 17.6%, Q3 18.8%, and Q4 26.1%, P < 0.001). The AUROC for the TyG index to predict NAFLD was 0.761, resulting in a cut-off value of 8.7. However, the AUC value of the TyG index was 0.589 for liver fibrosis, which was insufficient to predict this condition. The adjusted odds of having hepatic steatosis or liver fibrosis were more strongly associated with TyG values compared with HOMA-IR.
The TyG index is positively related to the severity of hepatic steatosis and the presence of liver fibrosis in NAFLD. The index also performed better than HOMA-IR.
三酰甘油-葡萄糖指数（TyG）是预测非酒精性脂肪性肝病（NAFLD）的可靠指标。但其与 NAFLD 中肝脂肪变性和肝纤维化严重程度的关系尚不清楚。本研究评估了这些因素在 NAFLD 中的关系。
共纳入 4784 名接受超声检查的参与者。评估了人体测量和生化指标。通过超声诊断 NAFLD 患者。使用瞬时弹性成像评估肝脂肪变性和肝硬度的程度。
TyG 指数与 NAFLD 患者肝脂肪变性的严重程度和肝纤维化的存在显著相关。TyG 四分位值与 NAFLD 的患病率增加相关（Q1 30.9%，Q2 53.3%，Q3 71.7%和 Q4 86.4%，P<0.001），也与肝纤维化的存在相关（Q1 13.5%，Q2 17.6%，Q3 18.8%和 Q4 26.1%，P<0.001）。TyG 指数预测 NAFLD 的 AUROC 为 0.761，截断值为 8.7。然而，TyG 指数预测肝纤维化的 AUC 值为 0.589，不足以预测该疾病。与 HOMA-IR 相比，调整后的 TyG 值与发生肝脂肪变性或肝纤维化的几率更密切相关。
TyG 指数与 NAFLD 中肝脂肪变性的严重程度和肝纤维化的存在呈正相关。该指数的表现也优于 HOMA-IR。
