Genova Pietro, Sorce Maria, Cabibi Daniela, Genova Gaspare, Gebbia Vittorio, Galanti Daniele, Galanti Daniela, Ancona Chiara, Valerio Maria Rosaria
Surgical Oncology Unit, Dipartimento di Scienze Chirurgiche, Oncologiche e Stomatologiche, University of Palermo, Palermo, Italy.
Dermatology Unit, Dipartimento Biomedico di Medicina Interna e Specialistica (DiBiMIS), University of Palermo, Palermo, Italy.
Case Rep Oncol Med. 2017;2017:2079068. doi: 10.1155/2017/2079068. Epub 2017 Oct 12.
The authors present a case of an 80-year-old Caucasian male with multiple gastric and rectal metastases from malignant melanoma presenting with hypochromic anemia as the sole symptom of disease without evidence of cutaneous and ocular tumor localization. The patient had a medical history positive for malignant lentigo melanoma of the occipital region of the scalp and early stage laryngeal squamous cell carcinoma and prostatic carcinoma treated with radiation therapy. The authors make some considerations on intestinal involvement by metastatic melanoma and discuss the choice of not treating with endoscopic procedures the gastric metastatic lesions most likely responsible for the clinical sign present at diagnosis. The patient was referred to clinical oncologists and received immunotherapy with ipilimumab and pembrolizumab.
作者报告了一例80岁的白种男性病例，该患者患有恶性黑色素瘤的多处胃和直肠转移，仅表现为低色素性贫血这一疾病症状，无皮肤和眼部肿瘤定位证据。患者有头皮枕部恶性雀斑样痣黑色素瘤病史，以及早期喉鳞状细胞癌和接受过放射治疗的前列腺癌病史。作者对转移性黑色素瘤累及肠道进行了一些思考，并讨论了不采用内镜手术治疗最可能导致诊断时出现临床症状的胃转移病变的选择。该患者被转诊至临床肿瘤学家处，并接受了伊匹单抗和帕博利珠单抗免疫治疗。
