Mocanu Valentin, Dang Jerry T, Switzer Noah, Skubleny Daniel, Shi Xinzhe, de Gara Chris, Birch Daniel W, Karmali Shahzeer
Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Department of Surgery, University of Alberta Hospital, 8440 112 Street NW, Edmonton, AB, T6G 2B7, Canada.
Obes Surg. 2018 Feb;28(2):567-573. doi: 10.1007/s11695-017-3024-8.
Helicobacter pylori (HP) occurs in 50% of people worldwide with higher rates reported in the bariatric population. HP has been associated with adverse outcomes following bariatric surgery; however, its true impact has not yet been defined. We aimed to systematically review the effect of HP on bariatric surgery outcomes. A comprehensive literature review was conducted yielding seven studies with 255,435 patients. Meta-analysis found comparable rates of bleeding, leak, hospital length of stay, and weight loss between HP-positive and HP-negative patients. HP was, however, found to be the largest independent predictor of marginal ulceration in those undergoing RYGB, with a tenfold increase versus HP-negative patients. Overall, HP is associated with increased marginal ulceration rates, but has little impact on other bariatric surgery outcomes.
幽门螺杆菌（HP）在全球50%的人群中存在，在肥胖症患者中的感染率更高。HP与肥胖症手术后的不良后果有关；然而，其真正影响尚未明确。我们旨在系统评价HP对肥胖症手术结局的影响。进行了全面的文献综述，纳入了7项研究，共255435例患者。荟萃分析发现，HP阳性和HP阴性患者在出血、渗漏、住院时间和体重减轻方面的发生率相当。然而，HP被发现是接受Roux-en-Y胃旁路术（RYGB）患者边缘性溃疡的最大独立预测因素，与HP阴性患者相比增加了10倍。总体而言，HP与边缘性溃疡发生率增加有关，但对其他肥胖症手术结局影响不大。
