直接电刺激人类大脑皮层会引发高频γ活动，这种活动可预测有意识的躯体感觉感知。
Direct electrical stimulation of human cortex evokes high gamma activity that predicts conscious somatosensory perception.
机构信息
Department of Biological Engineering, University of California, San Francisco, San Francisco, CA, United States of America. Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, United States of America.
出版信息
J Neural Eng. 2018 Apr;15(2):026015. doi: 10.1088/1741-2552/aa9bf9.
OBJECTIVE
Direct electrical stimulation (DES) is a clinical gold standard for human brain mapping and readily evokes conscious percepts, yet the neurophysiological changes underlying these percepts are not well understood.
APPROACH
To determine the neural correlates of DES, we stimulated the somatosensory cortex of ten human participants at frequency-amplitude combinations that both elicited and failed to elicit conscious percepts, meanwhile recording neural activity directly surrounding the stimulation site. We then compared the neural activity of perceived trials to that of non-perceived trials.
MAIN RESULTS
We found that stimulation evokes distributed high gamma activity, which correlates with conscious perception better than stimulation parameters themselves.
SIGNIFICANCE
Our findings suggest that high gamma activity is a reliable biomarker for perception evoked by both natural and electrical stimuli.
目的
直接电刺激（DES）是人类大脑映射的临床金标准，可轻易引发意识知觉，但这些知觉背后的神经生理变化尚不清楚。
方法
为了确定 DES 的神经相关性，我们以既能引发又不能引发意识知觉的频率-幅度组合刺激十名人类参与者的躯体感觉皮层，同时记录刺激部位周围的神经活动。然后，我们将感知试验的神经活动与非感知试验的神经活动进行比较。
主要结果
我们发现，刺激会引发分布式高伽马活动，与意识知觉的相关性比刺激参数本身更好。
意义
我们的发现表明，高伽马活动是由自然和电刺激引起的知觉的可靠生物标志物。
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