利用光引发活性分散聚合制备的负载一氧化氮纳米颗粒进行生物膜分散：形态学的影响
Biofilm dispersal using nitric oxide loaded nanoparticles fabricated by photo-PISA: influence of morphology.
作者信息
Sadrearhami Zahra, Yeow Jonathan, Nguyen Thuy-Khanh, Ho Kitty K K, Kumar Naresh, Boyer Cyrille
机构信息
Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW Australia, Sydney, NSW 2052, Australia.
出版信息
Chem Commun (Camb). 2017 Nov 30;53(96):12894-12897. doi: 10.1039/c7cc07293g.
Polymeric nanoparticles (NPs) of different morphologies (spheres and worms) were synthesized using a visible light mediated polymerization-induced self-assembly (PISA) approach. Spherical and worm-like NPs were subsequently modified to generate diazeniumdiolate functionalized NPs. Interestingly, the NO release rate and the dispersal of biofilms were found to strongly depend on the NP morphology. NPs with a higher aspect ratio (worms) exhibited a slower NO release rate and greater biofilm dispersal after 1 h of incubation.
使用可见光介导的聚合诱导自组装（PISA）方法合成了不同形态（球形和蠕虫状）的聚合物纳米颗粒（NPs）。随后对球形和蠕虫状纳米颗粒进行修饰，以生成二氮烯二醇盐功能化纳米颗粒。有趣的是，发现一氧化氮释放速率和生物膜的分散性强烈依赖于纳米颗粒的形态。长径比更高的纳米颗粒（蠕虫状）在孵育1小时后表现出较慢的一氧化氮释放速率和更大的生物膜分散性。
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