Rabhi Nabil, Hannou Sarah Anissa, Froguel Philippe, Annicotte Jean-Sébastien
Lille University, UMR 8199-EGID, Lille, France.
CNRS, UMR 8199, Lille, France.
Front Endocrinol (Lausanne). 2017 Nov 3;8:304. doi: 10.3389/fendo.2017.00304. eCollection 2017.
Chromatin architectures and epigenetic fingerprint regulation are fundamental for genetically determined biological processes. Chemical modifications of the chromatin template sensitize the genome to intracellular metabolism changes to set up diverse functional adaptive states. Accumulated evidence suggests that the action of epigenetic modifiers is sensitive to changes in dietary components and cellular metabolism intermediates, linking nutrition and energy metabolism to gene expression plasticity. Histone posttranslational modifications create a code that acts as a metabolic sensor, translating changes in metabolism into stable gene expression patterns. These observations support the notion that epigenetic reprograming-linked energy input is connected to the etiology of metabolic diseases and cancer. In the present review, we introduce the role of epigenetic cofactors and their relation with nutrient intake and we question the links between epigenetic regulation and the development of metabolic diseases.
染色质结构和表观遗传指纹调控对于基因决定的生物学过程至关重要。染色质模板的化学修饰使基因组对细胞内代谢变化敏感，从而建立多种功能性适应状态。越来越多的证据表明，表观遗传修饰因子的作用对饮食成分和细胞代谢中间体的变化敏感，将营养和能量代谢与基因表达可塑性联系起来。组蛋白翻译后修饰产生一种代码，作为代谢传感器，将代谢变化转化为稳定的基因表达模式。这些观察结果支持这样一种观点，即与表观遗传重编程相关的能量输入与代谢疾病和癌症的病因有关。在本综述中，我们介绍了表观遗传辅因子的作用及其与营养摄入的关系，并质疑表观遗传调控与代谢疾病发展之间的联系。
