Department of Otorhinolaryngology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Eur Rev Med Pharmacol Sci. 2017 Nov;21(21):4891-4895.
To investigate the relationship between the expression of glucose transporter-1 (GLUT-1) and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC).
Sixty-three patients with NPC (the NPC group) and 24 patients with chronic nasopharyngitis (the control group) who were treated between December 2014 and February 2016 were selected for this study. Pathological nasopharyngeal tissues were collected from patients. The expression of GLUT-1 was detected by immunohistochemistry. The expression of GLUT-1 was correlated with clinicopathological features and survival time.
The positive GLUT-1 expression rate in the NPC group was 58.73% (37/63), which was significantly higher than in the control group (29.17%, 7/24) (p<0.01). The positive GLUT-1 expression rate was significantly correlated with clinical stage, lymph node metastasis, and Epstein-Barr (EB) virus infection (p<0.05). The 3-year survival rate of GLUT-1-positive NPC patients was 75.00% and was significantly lower than that of GLUT-1-negative NPC patients (88.89%) (p<0.05).
GLUT-1 was highly expressed in the nasopharyngeal tissues of patients with NPC, and its expression was associated with clinical stage, lymph node metastasis, and EB virus infection.
研究葡萄糖转运蛋白-1（GLUT-1）的表达与鼻咽癌（NPC）患者的临床病理特征和预后的关系。
选取 2014 年 12 月至 2016 年 2 月期间收治的 63 例 NPC 患者（NPC 组）和 24 例慢性鼻咽炎患者（对照组）进行本研究。收集患者的病理鼻咽组织，采用免疫组织化学法检测 GLUT-1 的表达，分析 GLUT-1 的表达与临床病理特征及生存时间的关系。
NPC 组中 GLUT-1 阳性表达率为 58.73%（37/63），明显高于对照组的 29.17%（7/24）（p<0.01）。GLUT-1 阳性表达率与临床分期、淋巴结转移和 Epstein-Barr（EB）病毒感染显著相关（p<0.05）。GLUT-1 阳性 NPC 患者的 3 年生存率为 75.00%，明显低于 GLUT-1 阴性 NPC 患者的 88.89%（p<0.05）。
NPC 患者鼻咽组织中 GLUT-1 呈高表达，其表达与临床分期、淋巴结转移和 EB 病毒感染有关。
