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养老院收治老年患者谵妄患病率的预测模型

A Predictive Model of the Prevalence of Delirium in Elderly Subjects Admitted to Nursing Homes.

作者信息

Perez-Ros Pilar, Martinez-Arnau Francisco Miguel, Baixauli-Alacreu Susana, Garcia-Gollarte Jose Fermin, Tarazona-Santabalbina Francisco

机构信息

Department of Nursing, Nursing Faculty, Universidad Catolica de Valencia San Vicente Martir, Valencia, Spain.

Department of Physiotherapy, Physiotherapy Faculty, Universitat de Valencia, Valencia, Spain.

出版信息

Endocr Metab Immune Disord Drug Targets. 2018;18(4):355-361. doi: 10.2174/1871530317666171120152048.

Abstract

INTRODUCTION

Delirium is common in geriatric patients admitted to nursing homes, with an incidence of 22-79% among long-term residents.

AIM

To establish a predictive model of the risk of delirium episodes in a sample of elderly people living in nursing homes.

MATERIAL AND METHODS

A retrospective, cross-sectional case-control study covering a period of 12 consecutive months (April 2014 - March 2015) was carried out. The included cases had suffered at least one episode of delirium during the study period. Sociodemographic and clinical variables as well as risk factors predisposing to or triggering episodes of delirium were recorded.

RESULTS

A total of 193 cases and 123 controls were recruited. The mean age of the cases was 89.6 years (SD 6.9), and 75.1% were women. The mean age of the controls was 84.7 years (SD 7.42), and 75.6% were women. The prevalence of delirium was 60.7%. The presence of infections (with the exception of urinary tract infections) was the variable offering the best predictive capacity (OR=7.08; 95% CI: 3.30-15.02; p<0.001). Other predictors of delirium were also identified, such as a previous diagnosis of dementia (OR=3.14; 95% CI: 1.81-5.45; p<0.001), the use of anticholinergic drugs (OR=2.98; 95% CI: 1.34-6.60; p=0.007), a diagnosis of depression (OR=1.92; 95% CI: 1.03-3.56; p=0.039), and urinary incontinence (OR=1.73; 95% CI: 0.97-3.08; p=0.065). The area under the curve (AUC) was 0.794 (95% CI: 0.74-0.84; p<0.001).

CONCLUSIONS

The prevalence of delirium among elderly subjects admitted to nursing homes was 60.7%. Infections (with the exception of urinary tract infections), dementia, anticholinergic drug use, depression and urinary incontinence were predictive of the presence of delirium.

摘要

引言

谵妄在入住养老院的老年患者中很常见,长期居住者的发病率为22%-79%。

目的

建立一个针对居住在养老院的老年人群样本中谵妄发作风险的预测模型。

材料与方法

开展了一项回顾性横断面病例对照研究,涵盖连续12个月(2014年4月至2015年3月)。纳入的病例在研究期间至少经历过一次谵妄发作。记录了社会人口统计学和临床变量以及易引发或触发谵妄发作的危险因素。

结果

共招募了193例病例和123例对照。病例的平均年龄为89.6岁(标准差6.9),75.1%为女性。对照的平均年龄为84.7岁(标准差7.42),75.6%为女性。谵妄的患病率为60.7%。感染(不包括尿路感染)是预测能力最强的变量(比值比=7.08;95%置信区间:3.30-15.02;p<0.001)。还确定了其他谵妄预测因素,如既往痴呆诊断(比值比=3.14;95%置信区间:1.81-5.45;p<0.001)、使用抗胆碱能药物(比值比=2.98;95%置信区间:1.34-6.60;p=0.007)、抑郁症诊断(比值比=1.92;95%置信区间:1.03-3.56;p=0.039)和尿失禁(比值比=1.73;95%置信区间:0.97-3.08;p=0.065)。曲线下面积(AUC)为0.794(95%置信区间:0.74-0.84;p<0.001)。

结论

入住养老院的老年受试者中谵妄的患病率为60.7%。感染(不包括尿路感染)、痴呆、使用抗胆碱能药物、抑郁症和尿失禁可预测谵妄的存在。

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