1 Department of Diagnostic Radiology, Section of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030-4009.
AJR Am J Roentgenol. 2018 Feb;210(2):271-278. doi: 10.2214/AJR.17.18708. Epub 2017 Nov 22.
The goals of this review are to provide background information on the definitions and applications of the general term "biomarker" and to highlight the specific roles of breast imaging biomarkers in research and clinical breast cancer care. A search was conducted of the main electronic biomedical databases (PubMed, Cochrane, Embase, MEDLINE [Ovid], Scopus, and Web of Science). The search was focused on review literature in general radiology and biomedical sciences and on reviews and primary research articles on biomarkers in breast imaging over the 15 years ending in June 2017. The keywords included "biomarker," "trial endpoints," "breast imaging," "breast cancer," "radiomics," and "precision medicine" in the titles and abstracts of the papers.
Clinical breast care and breast cancer-related research rely on imaging biomarkers for decision support. In the era of precision medicine and big data, the practice of radiology is likely to change. A closer integration of breast imaging with related biomedical fields and the creation of large integrated and shareable databases of clinical, molecular, and imaging biomarkers should allow the field to continue guiding breast cancer care and research.
本综述旨在提供通用术语“生物标志物”的定义和应用背景信息，并强调乳腺影像学生物标志物在研究和临床乳腺癌护理中的具体作用。在主要电子生物医学数据库（PubMed、Cochrane、Embase、MEDLINE [Ovid]、Scopus 和 Web of Science）中进行了检索。检索主要集中在一般放射学和生物医学科学的综述文献，以及 2017 年 6 月结束的 15 年来乳腺影像学生物标志物的综述和原始研究文章。文献的标题和摘要中包含了“生物标志物”、“试验终点”、“乳腺成像”、“乳腺癌”、“放射组学”和“精准医学”等关键词。
临床乳腺护理和乳腺癌相关研究依赖于成像生物标志物来提供决策支持。在精准医学和大数据时代，放射科的实践可能会发生变化。乳腺影像学与相关生物医学领域更紧密地结合，以及建立包含临床、分子和影像学生物标志物的大型集成和可共享数据库，应该能够使该领域继续指导乳腺癌护理和研究。
