Reece E A, Gabrielli S, Abdalla M, O'Connor T, Bargar M, Hobbins J C
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Am J Obstet Gynecol. 1989 Feb;160(2):383-4. doi: 10.1016/0002-9378(89)90452-3.
The oral glucose tolerance test is the recommended method for the assessment of carbohydrate metabolism in pregnancy. However, available glucose drinks are often associated with varying degrees of gastrointestinal symptoms that might preclude meaningful studies. Polycose (Ross Labs, Columbus, Ohio) is a glucose saccharide polymer mixture containing 3% glucose, 7% maltose, 5% maltotriose, and 85% polysaccharide of 4 to 15 glucose units, with an osmotic load one fifth that of glucose. We assessed the efficacy of this glucose polymer in the performance of a 3-hour carbohydrate tolerance test with glucose and glucose polymer used 3 to 5 days apart in each patient tested. After 2 days of 300 gm carbohydrate-enriched diets, 48 patients underwent 3-hour carbohydrate tolerance tests at a mean gestational age of 30 +/- 3 weeks. Statistical analysis revealed a moderate level of agreement (kappa = 0.45, p less than 0.001) between the results of both carbohydrate tolerance test preparations. Patients experienced fewer gastrointestinal symptoms with the glucose polymer than with glucose. These preliminary data suggest that glucose polymer may be effectively used in the performance of a 3-hour carbohydrate tolerance test.
口服葡萄糖耐量试验是评估孕期碳水化合物代谢的推荐方法。然而，现有的葡萄糖饮料常常伴有不同程度的胃肠道症状，这可能会妨碍有意义的研究。聚葡萄糖（罗斯实验室，俄亥俄州哥伦布市）是一种葡萄糖聚合物混合物，含有3%的葡萄糖、7%的麦芽糖、5%的麦芽三糖以及85%由4至15个葡萄糖单位组成的多糖，其渗透压负荷仅为葡萄糖的五分之一。我们评估了这种葡萄糖聚合物在进行3小时碳水化合物耐量试验中的效果，在每位受试患者中，分别间隔3至5天使用葡萄糖和葡萄糖聚合物进行试验。在进行了2天富含300克碳水化合物的饮食后，48名患者在平均孕周为30±3周时接受了3小时碳水化合物耐量试验。统计分析显示，两种碳水化合物耐量试验制剂的结果之间存在中等程度的一致性（kappa = 0.45，p < 0.001）。与葡萄糖相比，患者使用葡萄糖聚合物时出现的胃肠道症状较少。这些初步数据表明，葡萄糖聚合物可有效地用于3小时碳水化合物耐量试验。
