Coustan D R, Widness J A, Carpenter M W, Rotondo L, Pratt D C, Oh W
Am J Obstet Gynecol. 1986 May;154(5):1031-5. doi: 10.1016/0002-9378(86)90744-1.
To determine whether the 50 gm, 1-hour plasma glucose screening test for gestational diabetes should be administered in the fasted or fed state, 50 presumed normal and 20 gestational diabetic pregnant women in the early third trimester underwent this test twice, once under each condition, within a 1-week interval. There was no difference in test results under the two conditions among the normal individuals (fasted 118.4 +/- 24.7 mg/dl; fed 115.8 +/- 23.4 mg/dl). However, when the test was administered to women with known gestational diabetes, the result was significantly (p = 0.011) higher if patients were fasted (173.9 +/- 28.8 mg/dl) than if they had been given a standard 600 kcal meal 1 hour previously (154.8 +/- 24.1 mg/dl). The effect of these two conditions on the sensitivity and specificity of the screening test is described, and it is suggested that the threshold for glucose tolerance testing be 130 mg/dl if the test is administered in the fed state.
为了确定妊娠糖尿病的50克1小时血浆葡萄糖筛查试验应在空腹还是进食状态下进行，50名假定正常的孕妇和20名妊娠糖尿病孕妇在妊娠晚期早期接受了两次该试验，在1周的间隔内，每种状态下各进行一次。正常个体在两种状态下的测试结果没有差异（空腹118.4±24.7毫克/分升；进食115.8±23.4毫克/分升）。然而，当对已知患有妊娠糖尿病的女性进行该试验时，如果患者空腹（173.9±28.8毫克/分升），结果显著（p = 0.011）高于1小时前给予标准600千卡餐食时（154.8±24.1毫克/分升）。描述了这两种状态对筛查试验敏感性和特异性的影响，并建议如果在进食状态下进行试验，葡萄糖耐量试验的阈值应为130毫克/分升。
