Gierek T, Lisiewicz J, Pilch J
J Maxillofac Surg. 1979 Aug;7(3):172-6. doi: 10.1016/s0301-0503(79)80036-3.
In patients with precancerous states and cancer of the larynx prior to and after radiotherapy exhibit the decreased activity of neutrophil beta-glucuronidase. Moreover patients treated by radiotherapy before the age of 6 to 9 years demonstrate deficiency of N-acetyl-beta-glucosaminidase in the above cells. The main finding in lymphocytes of the patients studied was in the appearance by diffusion of the above enzymes and of acid phosphatase in the cytoplasm, reflecting their release from lysosomes and immunological mobilization of these cells. The authors discuss the possible role of neutrophil enzymatic deficiency in lowering the antitumour cytotoxic effect of these cells.
在癌前状态患者以及喉癌患者放疗前后，中性粒细胞β - 葡萄糖醛酸酶的活性降低。此外，6至9岁之前接受放疗的患者，上述细胞中N - 乙酰 - β - 氨基葡萄糖苷酶缺乏。所研究患者淋巴细胞的主要发现是，上述酶以及酸性磷酸酶在细胞质中呈弥散状出现，这反映了它们从溶酶体中释放以及这些细胞的免疫动员。作者讨论了中性粒细胞酶缺乏在降低这些细胞抗肿瘤细胞毒性作用方面可能发挥的作用。
