喉癌及其他恶性肿瘤患者免疫系统细胞的酶缺乏症。

Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.

作者信息

Gierek T, Lisiewicz J, Moszczyński P, Pilch J, Namysłowski G

出版信息

Auris Nasus Larynx. 1985;12(1):47-51. doi: 10.1016/s0385-8146(85)80079-1.

Abstract

Activity of N-acetyl-beta-D-glucosaminidase, beta-glucuronidase, and acid phosphatase and myeloperoxidase was determined in neutrophils and lymphocytes of patients with cancer of the larynx and precancerous states of the larynx as well as--for comparative reasons--in patients with malignant tumors of female generation organs, breast carcinoma, cancer of the stomach and endometriosis. The main result of investigations performed was in fact that intracellular deficiency of beta-glucuronidase within the neutrophils characterizes patients with cancer and precancerous states of the larynx. Patients with cancer of the larynx show additionally a deficiency of neutrophil myeloperoxidase. Deficiency of N-acetyl-beta-D-glucosaminidase occurs, in contrast, in patients with malignancies of female generation organ. Activity of myeloperoxidase in neutrophils from patients with gastric carcinoma is slightly elevated.

摘要

对喉癌患者、喉癌癌前状态患者的中性粒细胞和淋巴细胞，以及出于比较目的对女性生殖器官恶性肿瘤患者、乳腺癌患者、胃癌患者和子宫内膜异位症患者，测定了N - 乙酰 - β - D - 氨基葡萄糖苷酶、β - 葡萄糖醛酸酶、酸性磷酸酶和髓过氧化物酶的活性。所进行研究的主要结果事实上是，中性粒细胞内β - 葡萄糖醛酸酶的细胞内缺乏是喉癌患者和喉癌癌前状态患者的特征。喉癌患者还表现出中性粒细胞髓过氧化物酶缺乏。相反，女性生殖器官恶性肿瘤患者存在N - 乙酰 - β - D - 氨基葡萄糖苷酶缺乏。胃癌患者中性粒细胞中的髓过氧化物酶活性略有升高。