Lisewicz J, Gierek T, Pilch J, Piastucka B
Med Interne. 1978 Jan-Mar;16(1):33-6.
Cytochemical investigations performed in 24 men with precancerous states of the larynx, i.e. leukoplakia, papillomas and pachydermia, indicated that the peripheral blood neutrophils from these patients exhibit a significant intracellular deficiency of beta-glucuronidase activity and of total lipids, as well as an increased alkaline phosphatase activity. Acid phosphatase and N-acetyl-beta-glucosaminidase activities did not differ significantly between patients and normal controls. In the authors' opinion, the neutrophil beta-glucuronidase deficiency might be a specific disturbance of neutrophils in the precancerous states and the cancer of the larynx. The possible significance of this disturbance and the subsequent decrease of antitumor immune reactivity are discussed.
对24名患有喉癌前病变（即白斑病、乳头状瘤和厚皮病）的男性进行的细胞化学研究表明，这些患者外周血中性粒细胞表现出细胞内β-葡萄糖醛酸酶活性和总脂质显著缺乏，以及碱性磷酸酶活性增加。患者与正常对照之间的酸性磷酸酶和N-乙酰-β-氨基葡萄糖苷酶活性没有显著差异。作者认为，中性粒细胞β-葡萄糖醛酸酶缺乏可能是喉癌前病变和癌症中中性粒细胞的一种特异性紊乱。讨论了这种紊乱的可能意义以及随后抗肿瘤免疫反应性的降低。
