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The big, the bad, and the exon 11: adjuvant imatinib for all gastro-intestinal stromal tumors or just the ugly?

作者信息

Groisberg Roman, Subbiah Vivek

机构信息

Department of Investigational Cancer Therapeutics (Phase 1 Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Transl Gastroenterol Hepatol. 2017 Oct 13;2:81. doi: 10.21037/tgh.2017.09.10. eCollection 2017.

DOI:10.21037/tgh.2017.09.10
PMID:29167828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5676203/
Abstract
摘要

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本文引用的文献

1
Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial.辅助伊马替尼治疗胃肠间质瘤患者中 KIT 和 PDGFRA 突变对生存的影响：一项随机临床试验的探索性分析。
JAMA Oncol. 2017 May 1;3(5):602-609. doi: 10.1001/jamaoncol.2016.5751.
2
BLU-285, DCC-2618 Show Activity against GIST.BLU-285 和 DCC-2618 对 GIST 具有活性。
Cancer Discov. 2017 Feb;7(2):121-122. doi: 10.1158/2159-8290.CD-NB2016-165. Epub 2017 Jan 11.
3
Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial.辅助伊马替尼治疗高危胃肠道间质瘤：一项随机试验分析。
J Clin Oncol. 2016 Jan 20;34(3):244-50. doi: 10.1200/JCO.2015.62.9170. Epub 2015 Nov 2.
4
Biomarker based clinical trial design.基于生物标志物的临床试验设计。
Chin Clin Oncol. 2014 Sep;3(3):39. doi: 10.3978/j.issn.2304-3865.2014.02.03.
5
The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.缺乏KIT和PDGFRA突变的胃肠道间质瘤的基因图谱
Endocrine. 2014 Nov;47(2):401-8. doi: 10.1007/s12020-014-0346-3. Epub 2014 Jul 16.
6
Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing.具有 KIT 外显子 9 突变的胃肠道间质瘤：基因型-表型相关性的最新研究和用于突变检测的高分辨率熔解曲线分析方法的验证。
Am J Surg Pathol. 2013 Nov;37(11):1648-59. doi: 10.1097/PAS.0b013e3182986b88.
7
The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.慢性髓性白血病（CML）药物的价格反映了癌症药物的不可持续价格：从一大群 CML 专家的角度来看。
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