Dertsiz Kozan Betül, Utlu Bahadır
Gazi Yaşargil Training and Research Hospital, Diyarbakır, Türkiye.
Erzurum Training and Research Hospital, Erzurum, Türkiye.
Aesthetic Plast Surg. 2025 Aug 28. doi: 10.1007/s00266-025-05206-y.
Upper eyelid blepharoplasty is one of the most frequently performed aesthetic surgeries in the world. The most important problem after aesthetic surgeries is scar formation. To investigate the effectiveness of Hypericum perforatum extract prepared with the traditional method on postoperative wound healing and scar appearance in patients who underwent upper eyelid blepharoplasty.
Patients who underwent blepharoplasty between January 2020 and January 2025 were divided into 2 groups: Group 1 (n=30, Hypericum perforatum extract applied), Group 2 (n=30, Hypericum perforatum extract not applied). All evaluations were evaluated by a single ophthalmologist at postoperative 2nd weeks, 1st month and 2nd months. At each follow-up, cases were evaluated using the REEDA wound healing (redness, edema, ecchymosis, discharge and approximation) and Vancouver scar (vascularity, pigmentation, pliability, and height) scale.
In our study, a total of 60 cases were examined, 30 in group 1 and 30 in group 2. 42 (70%) of the cases were female and 18 (30%) were male. The mean age was 43.2 ± 2.6 (25-75) years. The changes in two scales at postoperative 2nd week, 1st month and 2nd month in group 1 and group 2 were statistically significant (p<0.05). The difference between group 1 and group 2 at postoperative 2nd week and 1st month in REEDA scale was statistically significant (p<0.05). The difference between group 1 and group 2 at postoperative 2nd month was not statistically significant (p>0.05). Vancouver scale was 6.1 ± 2.2(3-13) in group 1 and 7.8 ± 3.1(4-13) in group 2 at postoperative 2nd week and the difference between the groups was statistically significant (p<0.05). There was no statistically significant difference between the groups at postoperative 1st and 2nd months (p>0.05).
Topical Hypericum perforatum extract had a positive effect on wound healing after blepharoplasty and did not have a significant effect on scar development in the long term.
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上睑成形术是全球最常开展的美容手术之一。美容手术后最重要的问题是瘢痕形成。本研究旨在探讨采用传统方法制备的贯叶连翘提取物对上睑成形术患者术后伤口愈合及瘢痕外观的影响。
将2020年1月至2025年1月期间接受睑成形术的患者分为2组：第1组（n = 30，应用贯叶连翘提取物），第2组（n = 30，未应用贯叶连翘提取物）。所有评估均由一名眼科医生在术后第2周、第1个月和第2个月进行。每次随访时，使用REEDA伤口愈合（发红、水肿、瘀斑、渗液和伤口对合情况）和温哥华瘢痕（血管分布、色素沉着、柔韧性和高度）量表对病例进行评估。
本研究共检查60例患者，第1组30例，第2组30例。42例（70%）为女性，18例（30%）为男性。平均年龄为43.2±2.6（25 - 75）岁。第1组和第2组在术后第2周、第1个月和第2个月时两个量表的变化具有统计学意义（p<0.05）。第1组和第2组在术后第2周和第1个月时REEDA量表的差异具有统计学意义（p<0.05）。第1组和第2组在术后第2个月时差异无统计学意义（p>0.05）。术后第2周时，第1组温哥华量表评分为6.1±2.2（3 - 13），第2组为7.8±3.1（4 - 13），两组间差异具有统计学意义（p<0.05）。术后第1个月和第2个月时两组间无统计学意义（p>0.05）。
局部应用贯叶连翘提取物对上睑成形术后伤口愈合有积极作用，但长期对瘢痕形成无显著影响。
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