Department of Medical Physics, Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Prof. Stanisława Łojasiewicza 11 Street, Kraków 30-348, Poland.
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, Lisboa 1649-028, Portugal.
Vascul Pharmacol. 2018 Feb;101:21-28. doi: 10.1016/j.vph.2017.11.006. Epub 2017 Nov 21.
Lactadherin is a small (53-66kDa) multifunctional glycoprotein belonging to the secreted extracellular matrix protein family. It has a multi-domain structure and is involved in many biological and physiological processes, including phagocytosis, angiogenesis, atherosclerosis, tissue remodeling, and haemostasis regulation. Lactadherin binds phosphatidylserine (PS)-enriched cell surfaces in a receptor-independent manner. Interaction between lactadherin and PS is crucial for regulation of blood coagulation processes. This review summarizes recent knowledge on the possible role of lactadherin in haemostasis control, emphasizing the great significance of the interaction between lactadherin and PS expressed on activated platelets and extracellular vesicles. The possible role of lactadherin as a therapeutic target and biomarker is also discussed.
乳铁蛋白是一种小（53-66kDa）多功能糖蛋白，属于分泌型细胞外基质蛋白家族。它具有多结构域结构，参与许多生物和生理过程，包括吞噬作用、血管生成、动脉粥样硬化、组织重塑和止血调节。乳铁蛋白以受体非依赖的方式与富含磷脂酰丝氨酸（PS）的细胞表面结合。乳铁蛋白与 PS 的相互作用对于调节凝血过程至关重要。本文综述了乳铁蛋白在止血控制中可能的作用的最新知识，强调了表达在活化血小板和细胞外囊泡上的乳铁蛋白与 PS 之间相互作用的重要意义。还讨论了乳铁蛋白作为治疗靶点和生物标志物的可能作用。
