Liu Yang, Zhang Panpan, Sun Hao
Department of Pediatrics, Dalian Municipal Women and Children's Medical Center (Group), Affiliated to Dalian Medical University, Dalian, Liaoning, China.
Front Psychiatry. 2025 May 23;16:1588135. doi: 10.3389/fpsyt.2025.1588135. eCollection 2025.
The role of gut microecology in attention deficit hyperactivity disorder (ADHD) has garnered growing attention. Studies have suggested a potential link between ADHD development and an imbalance in gut microbiota composition. This review aims to analyze the characteristics of the gut microbiota in children with ADHD, explore how changes in the gut microbiota affect ADHD through nervous, neuroendocrine, and immune pathways, and discuss the potential application of microecological agents and fecal microbiota transplantation in the prevention and treatment of ADHD in children. Pubmed, Google Scholar, EBSCO, Scopus and Medline were utilized to conduct searches using the following key terms:Attention Deficit Hyperactivity Disorder OR ADHD AND gut microbiota OR probiotics OR prebiotics OR synbiotics OR fecal microbiota transplantation OR FMT. Studies published in English from all years were included. A thorough review of numerous papers and their references was conducted to identify relevant articles. Sorting and analysis revealed that the gut microbiota of children with ADHD has changed to some extent, and targeting the gut microbiota, using microecological agents or fecal microbiota transplantation, especially in combination with central nervous system stimulants, may provide additional benefits for children with ADHD.
肠道微生态在注意力缺陷多动障碍（ADHD）中的作用已日益受到关注。研究表明，ADHD的发展与肠道微生物群组成的失衡之间可能存在联系。本综述旨在分析ADHD患儿肠道微生物群的特征，探讨肠道微生物群的变化如何通过神经、神经内分泌和免疫途径影响ADHD，并讨论微生态制剂和粪便微生物群移植在儿童ADHD预防和治疗中的潜在应用。利用Pubmed、Google Scholar、EBSCO、Scopus和Medline，使用以下关键词进行检索：注意力缺陷多动障碍或ADHD与肠道微生物群或益生菌或益生元或合生元或粪便微生物群移植或FMT。纳入所有年份以英文发表的研究。对大量论文及其参考文献进行了全面审查，以确定相关文章。整理和分析表明，ADHD患儿的肠道微生物群已发生一定程度的变化，针对肠道微生物群，使用微生态制剂或粪便微生物群移植，尤其是与中枢神经系统兴奋剂联合使用，可能会给ADHD患儿带来额外益处。
