Yokota S, Taniwaki M, Okuda T, Maekawa T, Nishida K, Misawa S, Takino T, Abe T, Urata Y
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Blut. 1989 Jan;58(1):27-31. doi: 10.1007/BF00320232.
We report here the development, 8 years after radiation therapy for breast cancer, of acute nonlymphocytic leukemia (ANLL), type M2 of the FAB classification, in which trisomy 4 was detected as the only chromosomal abnormality. Simultaneous observation of cytologic and cytogenetic features of individual colonies derived from leukemic progenitor (L-CFU) and early progenitor (CFU mix) cultures in this patient revealed that all colonies examined had a normal karyotype, although the clone with trisomy 4 was predominant in the direct bone-marrow culture. These findings suggest that progenitor cells with trisomy 4 were less predominant in colony growth when stimulated by colony-stimulating factors (CSFs) than were stem cells with a normal karyotype.
我们在此报告，一名乳腺癌患者在接受放射治疗8年后发生了急性非淋巴细胞白血病（ANLL），FAB分类为M2型，其中检测到4号染色体三体是唯一的染色体异常。对该患者白血病祖细胞（L-CFU）和早期祖细胞（CFU mix）培养物中单个集落的细胞学和细胞遗传学特征进行同步观察发现，尽管4号染色体三体的克隆在直接骨髓培养中占主导，但所有检测的集落核型均正常。这些发现表明，在集落刺激因子（CSF）刺激下，4号染色体三体的祖细胞在集落生长中的优势不如核型正常的干细胞。
