Horsman D E, Pantzar J T, Kalousek D K
Department of Pathology, Cancer Control Agency of British Columbia, Vancouver General Hospital, Canada.
Cancer Genet Cytogenet. 1988 Dec;36(2):155-7. doi: 10.1016/0165-4608(88)90138-0.
Trisomy 4 has recently been identified as a nonrandom chromosomal abnormality associated with acute nonlymphocytic leukemia with myelomonocytic morphology (AML M4). It has been suggested that it may be related to a new type of environmental toxin exposure. During the 1975-1987 period we have detected only one case of simple trisomy 4 in over 1200 patients successfully investigated for hematologic malignancy; this patient was diagnosed as having AML M2 and did not have a history of toxic chemical or drug exposure.
4号染色体三体最近被确定为一种与具有粒单核细胞形态的急性非淋巴细胞白血病（AML M4）相关的非随机染色体异常。有人提出它可能与一种新型环境毒素暴露有关。在1975年至1987年期间，在1200多名成功接受血液系统恶性肿瘤检查的患者中，我们仅检测到1例单纯4号染色体三体；该患者被诊断为AML M2，且没有接触有毒化学物质或药物的病史。
