F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute and the Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute and the Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Curr Opin Microbiol. 2017 Dec;40:131-137. doi: 10.1016/j.mib.2017.11.012. Epub 2017 Nov 22.
Fungi are ubiquitous microbes that are common in diverse environments including as commensal organisms on the human body. In addition to its obvious role as a digestive organ, the intestines have been further appreciated as important for the development, maintenance, and instruction of the immune system. The gut harbors many types of microorganisms including bacteria, archaea, fungi, and viruses, and many studies over the past couple of decades have documented an important role for intestinal bacteria in immunological function. Recent studies are now suggesting that intestinal fungi (the gut 'mycobiome') may similarly play important roles in host immunity and inflammation. This review will discuss recent studies that will influence our growing understanding of the role(s) of intestinal fungi in health and disease.
真菌是无处不在的微生物，在各种环境中都很常见，包括作为人体共生生物。除了作为消化器官的明显作用外，肠道在免疫系统的发育、维持和指导方面也具有重要意义。肠道中存在许多类型的微生物，包括细菌、古菌、真菌和病毒，过去几十年的许多研究都记录了肠道细菌在免疫功能中的重要作用。最近的研究表明，肠道真菌（肠道“真菌组”）可能在宿主免疫和炎症中同样发挥重要作用。本文综述将讨论近期的研究进展，这些研究将影响我们对肠道真菌在健康和疾病中的作用的不断深入理解。
