Kim Yoon Seob, Park Sang Hyun, Han Kyungdo, Lee Ji Hyun, Kim Nack In, Roh Joo Young, Seo Seong Jun, Song Hae Jun, Lee Min Geol, Choi Jee Ho, Park Young Min
Department of Dermatology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Department of Medical Statistics, The Catholic University of Korea College of Medicine, Seoul, Korea.
Allergy Asthma Immunol Res. 2018 Jan;10(1):83-87. doi: 10.4168/aair.2018.10.1.83.
Knowledge of the clinical course of chronic spontaneous urticaria (CSU) remains unclear. The purpose of our study was to investigate the clinical course of CSU in the Korean adult population. Each patient in the CSU group who was defined by disease codes between 2003 and 2007 was tracked whether he or she went into remission or not until 2013. Kaplan-Meier survival analysis was carried out to analyze remission, and log-rank tests were performed for between-group comparisons. Demographic differences between subjects who went into remission 1 year after the initial diagnosis and those who did not were analyzed using χ² tests. A total of 13,969 subjects were included in the CSU group. The 1-, 2-, 3-, 4-, and 5-year remission rates of CSU were 21.5%, 33.0%, 38.9%, 42.6%, and 44.6%, respectively. The proportion of subjects in the 65+ age group (P=0.050) and with male gender (P=0.002) was significantly higher among subjects who did not go into remission 1 year after the initial diagnosis. Our study indicates that CSU could have a more persistent course than previously reported.
慢性自发性荨麻疹（CSU）的临床病程仍不明确。我们研究的目的是调查韩国成年人群中CSU的临床病程。对2003年至2007年间由疾病编码定义的CSU组中的每位患者进行追踪，直至2013年，观察其是否缓解。采用Kaplan-Meier生存分析来分析缓解情况，并进行对数秩检验以进行组间比较。使用χ²检验分析初次诊断后1年缓解的受试者与未缓解的受试者之间的人口统计学差异。CSU组共纳入13969名受试者。CSU的1年、2年、3年、4年和5年缓解率分别为21.5%、33.0%、38.9%、42.6%和44.6%。初次诊断后1年未缓解的受试者中，65岁及以上年龄组（P=0.050）和男性（P=0.002）的比例显著更高。我们的研究表明，CSU的病程可能比先前报道的更持久。
