Metz Sophie, Aust Sabine, Fan Yan, Bönke Luisa, Harki Zjala, Gärtner Matti, Bajbouj Malek, Grimm Simone
Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
Behav Brain Res. 2018 Feb 26;339:179-185. doi: 10.1016/j.bbr.2017.11.022. Epub 2017 Nov 24.
Early life stress (ELS) impacts emotional and cognitive competences. We aimed to investigate whether the effects of ELS on working memory (WM) performance depend on the valence of the stimuli.
Between January and October 2015, we recruited (N=31) healthy subjects with (N=15) and without (N=16) ELS experiences. Participants performed a WM-task with emotional stimuli.
Results show a trend towards decreased WM accuracy in subjects with ELS experiences (p=.06) with increased WM accuracy (p=.08) and an altered pattern of BOLD responses in the left posterior cingulate cortex (PCC)/precuneus (p<.001) and the rostral anterior cingulate cortex (rACC) (p<.01) in response to negative stimuli.
The small sample size and potential confounding factors should be considered when interpreting the results.
Our data suggests that negative valence influences cognitive performance and brain activity in subjects with ELS experiences.
早年生活应激（ELS）会影响情绪和认知能力。我们旨在研究ELS对工作记忆（WM）表现的影响是否取决于刺激的效价。
2015年1月至10月期间，我们招募了31名健康受试者，其中15名有ELS经历，16名没有ELS经历。参与者对情绪刺激执行WM任务。
结果显示，有ELS经历的受试者WM准确性有下降趋势（p = 0.06），而WM准确性有所提高（p = 0.08），并且在对负面刺激的反应中，左后扣带回皮质（PCC）/楔前叶（p < 0.001）和喙前扣带回皮质（rACC）（p < 0.01）的BOLD反应模式发生了改变。
在解释结果时应考虑样本量小和潜在的混杂因素。
我们的数据表明，负效价会影响有ELS经历的受试者的认知表现和大脑活动。
