Iovino Francesco, Auriemma Pasquale Pio, Dani Luca, Donnarumma Giovanna, Barbarisi Alfonso, Mallardo Vincenza, Calò Federica, Coppola Nicola
Division of General Surgery, Department of Cardiothoracic and Respiratory Science, University of Campania "Luigi Vanvitelli", Naples, Italy.
Division of General Surgery, Department of Cardiothoracic and Respiratory Science, University of Campania "Luigi Vanvitelli", Naples, Italy.
J Surg Res. 2017 Dec;220:268-274. doi: 10.1016/j.jss.2017.07.029. Epub 2017 Aug 17.
Surgical site infection (SSI) is a common complication of surgical procedures.
Our study aimed at investigating a new method based on assessment of suture thread colonization to identify patients developing an SSI.
We prospectively enrolled 119 patients undergoing elective surgery. For each patient, a synthetic absorbable thread in Lactomer 9-1 (Polisorb Gauge 2) inserted in the surgical site at the end of surgery was sent to the microbiology laboratory after 48 h to assess colonization of its inner tract.
Forty (33.6% of cases) patients had a colonized thread. Antibiotic prophylaxis was administered to 66 of 79 patients who did not display a colonized thread and to 20 of the 40 patients with a colonized thread (83.5% versus 50%, respectively, P = 0.0002). An SSI was observed only in patients with a colonized thread (10% versus 0, P = 0.02). The microorganisms identified in colonized threads were the same identified in SSIs.
Since an SSI was found only in patients with colonized threads, the method described here may be valuable for identifying patients developing an SSI. Moreover, the method can also be useful for targeting efficient antibiotic therapy to the culprit microorganisms.
手术部位感染（SSI）是外科手术常见的并发症。
我们的研究旨在探究一种基于评估缝线定植情况来识别发生手术部位感染患者的新方法。
我们前瞻性纳入了119例行择期手术的患者。对于每位患者，在手术结束时插入手术部位的一根Lactomer 9-1（Polisorb规格2）合成可吸收缝线，在48小时后送至微生物实验室以评估其内部通道的定植情况。
40例（占病例的33.6%）患者的缝线发生了定植。在79例缝线未发生定植的患者中有66例接受了抗生素预防，在40例缝线发生定植的患者中有20例接受了抗生素预防（分别为83.5%和50%，P = 0.0002）。仅在缝线发生定植的患者中观察到手术部位感染（10%对0，P = 0.02）。在定植的缝线中鉴定出的微生物与在手术部位感染中鉴定出的微生物相同。
由于仅在缝线发生定植的患者中发现了手术部位感染，本文所述方法可能对识别发生手术部位感染的患者有价值。此外，该方法还可用于针对致病微生物进行有效的抗生素治疗。
