Department of Plant and Microbial Biology, University of California, Berkeley, CA, 94720, USA.
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Nat Commun. 2017 Nov 27;8(1):1814. doi: 10.1038/s41467-017-02018-w.
Preterm infants exhibit different microbiome colonization patterns relative to full-term infants, and it is speculated that the hospital room environment may contribute to infant microbiome development. Here, we present a genome-resolved metagenomic study of microbial genotypes from the gastrointestinal tracts of infants and from the neonatal intensive care unit (NICU) room environment. Some strains detected in hospitalized infants also occur in sinks and on surfaces, and belong to species such as Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumoniae, which are frequently implicated in nosocomial infection and preterm infant gut colonization. Of the 15 K. pneumoniae strains detected in the study, four were detected in both infant gut and room samples. Time series experiments showed that nearly all strains associated with infant gut colonization can be detected in the room after, and often before, detection in the gut. Thus, we conclude that a component of premature infant gut colonization is the cycle of microbial exchange between the room and the occupant.
早产儿的微生物组定植模式与足月儿不同，有人推测，医院病房环境可能有助于婴儿微生物组的发育。在这里，我们呈现了一项针对婴儿胃肠道和新生儿重症监护病房（NICU）病房环境中微生物基因型的基于基因组的宏基因组研究。在住院婴儿中检测到的一些菌株也存在于水槽和表面上，属于表皮葡萄球菌、粪肠球菌、铜绿假单胞菌和肺炎克雷伯菌等物种，这些物种经常与医院获得性感染和早产儿肠道定植有关。在本研究中检测到的 15 株肺炎克雷伯菌中，有 4 株同时存在于婴儿肠道和病房样本中。时间序列实验表明，几乎所有与婴儿肠道定植相关的菌株都可以在肠道检测到后，并且通常在肠道检测到之前，在病房中检测到。因此，我们得出结论，早产儿肠道定植的一个组成部分是微生物在房间和居住者之间的循环交换。
