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Curcumin and (-)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells.姜黄素和（-）-表没食子儿茶素-3-没食子酸酯可减轻丙烯酰胺诱导的HepG2细胞增殖。
Food Chem Toxicol. 2014 Apr;66:194-202. doi: 10.1016/j.fct.2014.01.046. Epub 2014 Feb 4.
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Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients.长期吸烟对胃癌患者脂质过氧化及抗氧化状态的影响。
Indian J Gastroenterol. 2009 Mar-Apr;28(2):65-7. doi: 10.1007/s12664-009-0021-4. Epub 2009 Aug 21.
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Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients.口腔鳞状细胞癌患者血液和肿瘤组织中的氧化还原状态。
Oral Dis. 2010 Jan;16(1):29-33. doi: 10.1111/j.1601-0825.2009.01598.x. Epub 2009 Jul 8.
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Reactive oxygen species-dependent signaling regulates cancer.活性氧物种依赖性信号传导调控癌症。
Cell Mol Life Sci. 2009 Dec;66(23):3663-73. doi: 10.1007/s00018-009-0099-y. Epub 2009 Jul 24.
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Prevention of skin cancer by green tea: past, present and future.绿茶对皮肤癌的预防：过去、现在与未来
Cancer Biol Ther. 2009 Jul;8(13):1288-91. doi: 10.4161/cbt.8.13.9022.
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Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors.茶多酚通过线粒体细胞死亡途径诱导小鼠皮肤肿瘤细胞凋亡。
Cancer Biol Ther. 2009 Jul;8(13):1281-7. doi: 10.4161/cbt.8.13.8728.
7
Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.哺乳动物细胞中细胞外抗氧化硒蛋白血浆谷胱甘肽过氧化物酶（GPx-3）的调控
Mol Cell Biochem. 2009 Jul;327(1-2):111-26. doi: 10.1007/s11010-009-0049-x. Epub 2009 Feb 15.
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N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility.用于抗氧化治疗的N-乙酰半胱氨酸：药理学与临床应用
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Multiple molecular targets in cancer chemoprevention by curcumin.姜黄素在癌症化学预防中的多个分子靶点。
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Inhibition of proliferation and induction of apoptosis by EGCG in human osteogenic sarcoma (HOS) cells.
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表没食子儿茶素-3-没食子酸酯对宫颈癌活检组织和HeLa细胞系中血红素加氧酶诱导的活性氧的比较疗效。

Comparative efficacy of epigallocatechin-3-gallate against HO-induced ROS in cervical cancer biopsies and HeLa cell lines.

作者信息

Hussain Sohail

机构信息

Department of Biochemistry, Faculty of Medicine, J. N. Medical College, Aligarh Muslim University, Aligarh, India.

Department of Biochemistry, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia (KSA).

出版信息

Contemp Oncol (Pozn). 2017;21(3):209-212. doi: 10.5114/wo.2017.70110. Epub 2017 Sep 29.

DOI:10.5114/wo.2017.70110
PMID:29180927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5701581/
Abstract

AIM OF THE STUDY

Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells.

MATERIAL AND METHODS

The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects. Thereafter, hydrogen peroxide (0-10 nM) - an ROS-generating compound - was co-cultured with varying doses of epigallocatechin-3-gallate (EGCG). The effect of this compound on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was assessed.

RESULT

The activity of SOD and GPx was protected significantly in the treatment of EGCG in cervical cancer biopsies and HeLa cell line.

HYPOTHESIS

It is hypothesised that EGCG has free radical scavenging properties.

CONCLUSIONS

EGCG protected the activity SOD and GPx equally in cervical cancer biopsies (CCB) and HeLa cell line.

摘要

研究目的

抗氧化剂在维持生理稳态中发挥重要作用。近期文献强调了天然抗氧化剂的潜在治疗作用，这些抗氧化剂具有抗炎和抗氧化作用，可用于预防氧化应激诱导的损伤，这是其发病机制的特征。本研究的目的是评估表没食子儿茶素没食子酸酯（EGCG）对HeLa细胞系和癌细胞的保护作用。

材料与方法

用不同剂量的抗氧化剂处理HeLa细胞系和宫颈癌活检组织（CCB），以确定其效果。此后，将过氧化氢（0 - 10 nM）——一种活性氧生成化合物——与不同剂量的表没食子儿茶素没食子酸酯（EGCG）共同培养。评估该化合物对超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性的影响。

结果

在宫颈癌活检组织和HeLa细胞系中，EGCG处理显著保护了SOD和GPx的活性。

假设

假设EGCG具有自由基清除特性。

结论

EGCG在宫颈癌活检组织（CCB）和HeLa细胞系中同样保护了SOD和GPx的活性。