Pasupathi Palanisamy, Saravanan Ganesan, Chinnaswamy Palanisamy, Bakthavathsalam Govindaswamy
Institute of Laboratory Medicine, K.G. Hospital, Coimbatore, Tamil Nadu, India,
Indian J Gastroenterol. 2009 Mar-Apr;28(2):65-7. doi: 10.1007/s12664-009-0021-4. Epub 2009 Aug 21.
Oxidative stress plays an important role in malignant transformation and is postulated to be associated with increased lipid peroxidation. We determined the effects of chronic cigarette smoking on lipid peroxidation and antioxidant status in 100 male patients with gastric cancer and an equal number of age-matched healthy control subjects. The mean (SD) level of thiobarbituric acid reactive substances (TBARS) was higher in plasma (healthy non-smokers 3.1 [0.2]; healthy smokers 4.6 [0.2]; gastric cancer non-smokers 6.5 [1.0]; gastric cancer smokers 8.9 [3.1]) and erythrocytes (3.3 [0.6]; 4.6 [0.1]; 8.3 [0.9]; 13.2 [5.1]) from gastric cancer patients when compared with control subjects. TBARS level was higher in smokers than non-smoking gastric cancer patients. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-treansferase, reduced glutathione, and vitamins A, E and C were decreased in gastric cancer patients who were smokers as compared to other groups (p<0.001). Thus, there occurs lipid peroxidation and possible breakdown of antioxidant status in cigarette smoking, which may increase the risk of gastric cancer.
氧化应激在恶性转化中起重要作用，据推测与脂质过氧化增加有关。我们测定了100例男性胃癌患者及同等数量年龄匹配的健康对照者中，长期吸烟对脂质过氧化和抗氧化状态的影响。血浆（健康非吸烟者3.1[0.2]；健康吸烟者4.6[0.2]；胃癌非吸烟者6.5[1.0]；胃癌吸烟者8.9[3.1]）和红细胞（3.3[0.6]；4.6[0.1]；8.3[0.9]；13.2[5.1]）中硫代巴比妥酸反应性物质（TBARS）的平均（标准差）水平，与对照者相比，胃癌患者更高。吸烟者的TBARS水平高于非吸烟胃癌患者。与其他组相比，吸烟的胃癌患者中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽-S-转移酶、还原型谷胱甘肽以及维生素A、E和C的活性降低（p<0.001）。因此，吸烟会发生脂质过氧化并可能导致抗氧化状态破坏，这可能增加胃癌风险。
