Steiner I, Wirguin I, Morag A, Abramsky O
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
J Child Neurol. 1989 Jan;4(1):20-4. doi: 10.1177/088307388900400103.
Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 x 10(6) IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE.
三名亚急性硬化性全脑炎（SSPE）患儿接受了α-干扰素治疗。通过奥马亚贮器向脑室系统给药，持续13至24个月，剂量逐渐增加，直至每周两次，每次1.0×10⁶国际单位。两名患儿临床症状有轻度改善，第三名患儿病情稳定，所有患者的脑电图记录均有改善，两名患儿脑脊液中的抗麻疹抗体减少。患者数量较少，无法确定这一病程是我们患者中SSPE的自然病程还是治疗所致，但似乎脑室内干扰素治疗可以改变SSPE的病程。
