亚急性硬化性全脑炎的长期肌内注射重组DNA干扰素α2治疗：血清麻疹抗体减少但无临床改善。

Long-term intramuscular recombinant DNA interferon alpha 2 therapy in subacute sclerosing panencephalitis: reduction of serum measles antibodies without clinical improvement.

作者信息

Crols R, Lowenthal A

出版信息

Eur Neurol. 1987;27(2):72-7. doi: 10.1159/000116134.

Abstract

Two patients with subacute sclerosing panencephalitis (SSPE) were treated intramuscularly with recombinant DNA interferon-alpha 2 for 3 and 6 months, respectively. Side effects were minimal. No objective clinical response could be noted. In a patient with stable SSPE, a significant decrease in serum antimeasles antibody levels was observed. This decrease was less pronounced in another patient with evolutive SSPE. The results of this study were compared to findings published previously. The reasons for the lack of clinical efficacy of interferon in SSPE are discussed.

摘要

两名亚急性硬化性全脑炎（SSPE）患者分别接受了3个月和6个月的重组DNA干扰素-α2肌肉注射治疗。副作用极小。未观察到客观的临床反应。在一名病情稳定的SSPE患者中，观察到血清抗麻疹抗体水平显著下降。在另一名病情进展的SSPE患者中，这种下降不太明显。本研究结果与先前发表的研究结果进行了比较。讨论了干扰素在SSPE中缺乏临床疗效的原因。