用钌（II）配合物进行内源性 CO 的离体追踪。
Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex.
机构信息
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València , 46022 Valencia, Spain.
Departamento de Química, Universitat Politècnica de València , Camino de Vera s/n, 46022 Valencia, Spain.
出版信息
J Am Chem Soc. 2017 Dec 27;139(51):18484-18487. doi: 10.1021/jacs.7b11158. Epub 2017 Dec 6.
A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.
一种基于钌（II）乙烯配合物的双光子荧光探针能够选择性地检测细胞和使用皮下气囊中作为炎症模型的小鼠中的一氧化碳。该探针将在现实模型中对内源性 CO 的高选择性和灵敏的体外检测与简便、廉价的合成相结合，并且与广泛使用的钯基体系相比具有许多优势。
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