Lambert R W, Smith R E
Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
J Invest Dermatol. 1989 Mar;92(3):321-5. doi: 10.1111/1523-1747.ep12277122.
Systemic administration of 13-cis-retinoic acid caused a reduction of acinar tissue in the hamster meibomian gland. Histologic examination of treated meibomian gland tissue revealed a thickening of gland ductal epithelium and a decrease in the numbers of mature lipid-laden acinar cells. Morphometric analysis showed a reduction of up to 75% in mean volume of meibomian acinar tissue from animals fed a high dose of 13-cis-retinoic acid. Clinical observations in these animals included alopecia and weight loss. Ocular complications included crusting of the eyelid margin and the external surface of the lid and erythema of the conjunctiva. The model supports previous observations by the authors that systemic 13-cis-retinoic acid affects meibomian gland structure in a laboratory animal. The ocular side effects described in this model suggest that future functional studies may yield important insights into the complex relationship between meibomian gland morphology and function, and events on the ocular surface.
全身性给予13 - 顺式视黄酸导致仓鼠睑板腺的腺泡组织减少。对经处理的睑板腺组织进行组织学检查发现，腺导管上皮增厚，成熟的充满脂质的腺泡细胞数量减少。形态计量分析显示，喂食高剂量13 - 顺式视黄酸的动物，睑板腺泡组织的平均体积减少了75%。这些动物的临床观察结果包括脱发和体重减轻。眼部并发症包括睑缘和眼睑外表面结痂以及结膜红斑。该模型支持了作者之前的观察结果，即全身性13 - 顺式视黄酸会影响实验动物的睑板腺结构。该模型中描述的眼部副作用表明，未来的功能研究可能会对睑板腺形态与功能以及眼表事件之间的复杂关系产生重要见解。
