Lambert R W, Smith R E
Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
Invest Ophthalmol Vis Sci. 1988 Oct;29(10):1559-64.
Systemic treatment of adult male New Zealand albino rabbits with 13-cis-retinoic acid (isotretinoin) resulted in a reduction in the size of the meibomian gland. Clinical signs of toxicity included weight loss, alopecia, dry skin and mild conjunctival erythema with crusting on the eyelid margin. Histopathologic findings included thickening of duct and ductule epithelium, decrease in acinar tissue, accentuation of basaloid cells and evidence of periacinar fibrosis. The model presents the first experimental data to indicate that systemic 13-cis-retinoic acid effects meibomian gland structure in a laboratory model. Future functional studies of this model may yield important insights into the relationships between meibomian gland morphology, function, the ocular surface and the pathogenesis of blepharo-conjunctivitis.
用13 - 顺式维甲酸（异维A酸）对成年雄性新西兰白化兔进行全身治疗，导致睑板腺大小减小。毒性的临床体征包括体重减轻、脱发、皮肤干燥以及轻度结膜红斑伴睑缘结痂。组织病理学发现包括导管和小导管上皮增厚、腺泡组织减少、基底样细胞增多以及腺泡周围纤维化的证据。该模型提供了首个实验数据，表明全身应用13 - 顺式维甲酸在实验室模型中会影响睑板腺结构。对该模型未来的功能研究可能会对睑板腺形态、功能、眼表和睑结膜炎发病机制之间的关系产生重要见解。
