School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Molecules. 2017 Nov 29;22(12):2097. doi: 10.3390/molecules22122097.
Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles.
鉴于杂环吲哚衍生物的重要性，人们已经投入大量精力开发在 N1 和 C3 位官能化吲哚核的方法。此外，铂催化的亲核试剂烯丙基化是一种成熟且有效的方法，已应用于药物和有机化学。在我们的研究中，研究了不同条件下带有烯丙基乙酸盐的铂催化 2,3-二取代吲哚。在此，我们建立了一种简单、方便、高效的方法，以高产率得到烯丙基化吲哚。
