Østfold Hospital Trust, Department of Gastroenterology, Grålum, Norway.
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
J Crohns Colitis. 2018 Mar 28;12(4):389-393. doi: 10.1093/ecco-jcc/jjx152.
An increased prevalence of irritable bowel syndrome [IBS]-like symptoms has been reported in patients with ulcerative colitis [UC]. Whether ongoing inflammation increases the prevalence of such symptoms is unknown. The aims of this study were to determine the prevalence of IBS-like symptoms in a population-based cohort of UC patients 20 years after diagnosis, and to assess the possible association between such symptoms and ongoing inflammation.
Patients diagnosed with UC between 1990 and 1994, in a geographically well-defined area, were included in a prospective follow-up study, and IBS symptoms according to Rome III criteria were recorded 20 years after diagnosis. The patients underwent colonoscopy with biopsies and/or the level of faecal calprotectin was analysed.
A total of 260 patients answered the Rome III questionnaire. The overall prevalence of IBS-like symptoms was 27%. In patients who had no signs of inflammation in colonic biopsies [n = 96] [deep remission], the prevalence was 29%. No difference in prevalence of IBS-like symptoms was found between patients with ongoing inflammation and patients in deep remission.
IBS-like symptoms in UC patients are frequent after 20 years of disease. Deep remission did not change the frequency of IBS-like symptoms.
溃疡性结肠炎[UC]患者中报告有较高的肠易激综合征[IBS]样症状的患病率。目前尚不清楚持续的炎症是否会增加此类症状的患病率。本研究的目的是确定诊断为 UC 20 年后的患者中 IBS 样症状的患病率，并评估此类症状与持续炎症之间的可能关联。
在地理上定义明确的区域中，于 1990 年至 1994 年间诊断为 UC 的患者被纳入前瞻性随访研究，根据罗马 III 标准记录诊断后 20 年的 IBS 症状。对患者进行结肠镜检查和/或粪便钙卫蛋白水平分析。
共有 260 名患者回答了罗马 III 问卷。IBS 样症状的总体患病率为 27%。在无结肠活检炎症迹象的患者[n=96] [深度缓解]中，患病率为 29%。在有持续炎症的患者和深度缓解的患者之间，IBS 样症状的患病率没有差异。
UC 患者在患病 20 年后 IBS 样症状较为常见。深度缓解并未改变 IBS 样症状的频率。
