Inflammatory Bowel Disease Center, Shimane University Hospital, Izumo, Japan,
Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Japan,
Digestion. 2019;99(1):46-51. doi: 10.1159/000494412. Epub 2018 Dec 14.
Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher in those without ongoing clinical activity as compared to healthy controls. Several studies have investigated residual low-grade inflammation found in colonic mucosa of quiescent UC patients and its association with development of IBS-like symptoms. In these patients, residual colonic inflammation was evaluated using endoscopy and histology findings, as well as fecal calprotectin level and shown to not be simply associated with the presence of IBS-like symptoms in UC patients in clinical remission. However, these results are limited by the low number of related investigations conducted. Additional appropriately designed studies are necessary to confirm the relationship of low-grade colonic inflammation with IBS-like symptoms associated with UC.
溃疡性结肠炎（UC）患者在临床缓解期常出现肠易激综合征（IBS）样症状。与健康对照组相比，无持续临床活动的 UC 患者符合 IBS 定义的患病率明显更高。多项研究调查了静止期 UC 患者结肠黏膜中发现的残留低度炎症及其与 IBS 样症状发展的关系。在这些患者中，残留结肠炎症通过内镜和组织学发现、粪便钙卫蛋白水平进行评估，且与 UC 患者临床缓解期出现 IBS 样症状并无直接关联。然而，这些结果受到相关研究数量较少的限制。需要更多设计合理的研究来证实低度结肠炎症与 UC 相关的 IBS 样症状之间的关系。
