Starzl T E, Rowe M I, Todo S, Jaffe R, Tzakis A, Hoffman A L, Esquivel C, Porter K A, Venkataramanan R, Makowka L
Department of Surgery, School of Pharmacy, University of Pittsburgh Health Center, University of Pittsburgh, Pa.
JAMA. 1989 Mar 10;261(10):1449-57.
Two children with the short-gut syndrome and secondary liver failure were treated with evisceration and transplantation en bloc of the stomach, small intestine, colon, pancreas, and liver. The first patient died perioperatively, but the second lived for more than 6 months before dying of an Epstein-Barr virus-associated lymphoproliferative disorder that caused biliary obstruction and lethal sepsis. There was never evidence of graft rejection or of graft-vs-host disease in the long-surviving child. The constituent organs of the homograft functioned and maintained their morphological integrity throughout the 193 days of survival.
两名患有短肠综合征和继发性肝衰竭的儿童接受了胃、小肠、结肠、胰腺和肝脏整块脏器去除及移植治疗。第一名患者在围手术期死亡，但第二名患者存活了6个多月，之后死于与爱泼斯坦-巴尔病毒相关的淋巴增生性疾病，该疾病导致胆管梗阻和致命性败血症。在长期存活的儿童中，从未有移植物排斥或移植物抗宿主病的证据。在整个193天的存活期内，同种异体移植物的组成器官发挥功能并保持其形态完整性。
