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血液和血浆中环孢素A的液相色谱测定法

Liquid-chromatographic determination of cyclosporin A in blood and plasma.

作者信息

Sawchuk R J, Cartier L L

出版信息

Clin Chem. 1981 Aug;27(8):1368-71.

PMID:7273396
Abstract

We describe a liquid-chromatographic assay for cyclosporin A in blood and plasma. The method is sensitive enough to allow quantitation of the drug at concentrations observed clinically, is isocratic, required no derivatization, and takes only 10 min of analysis time.

摘要

我们描述了一种用于血液和血浆中环孢素A的液相色谱测定法。该方法灵敏度足以对临床观察到的药物浓度进行定量，采用等度洗脱，无需衍生化，且分析时间仅需10分钟。

相似文献

1
Liquid-chromatographic determination of cyclosporin A in blood and plasma.血液和血浆中环孢素A的液相色谱测定法
Clin Chem. 1981 Aug;27(8):1368-71.
2
Simplified liquid-chromotographic analysis for cyclosporin A, and comparison with radioimmunoassay.
Clin Chem. 1983 Jan;29(1):180-3.
3
Reversed-phase high-performance liquid chromatography determination of cyclosporin in human blood.
Ther Drug Monit. 1987 Sep;9(3):353-7. doi: 10.1097/00007691-198709000-00017.
4
Rapid, sensitive high-performance liquid chromatographic method for the determination of cyclosporin A and its metabolites M1, M17 and M21.快速、灵敏的高效液相色谱法测定环孢素A及其代谢物M1、M17和M21。
J Chromatogr B Biomed Sci Appl. 1997 Mar 7;690(1-2):367-72. doi: 10.1016/s0378-4347(96)00364-7.
5
High pressure liquid chromatographic determination of cyclosporin A in plasma.
J Clin Hosp Pharm. 1981 Sep;6(3):195-9. doi: 10.1111/j.1365-2710.1981.tb00992.x.
6
Improved high-performance liquid chromatographic method for analysis of cyclosporin A using an automated sample processor.使用自动进样器的改进型高效液相色谱法分析环孢素A
J Chromatogr. 1990 Jan 26;525(1):123-32. doi: 10.1016/s0378-4347(00)83385-x.
7
High-performance liquid chromatographic analysis of cyclosporin G (Nva2-cyclosporine) in human blood.人血中环孢菌素G（Nva2-环孢素）的高效液相色谱分析
Ther Drug Monit. 1992 Oct;14(5):397-401. doi: 10.1097/00007691-199210000-00010.
8
Determination of cyclosporin A in whole blood by high-performance liquid chromatography using automated column switching.
J Chromatogr. 1986 Dec 19;383(2):349-55. doi: 10.1016/s0378-4347(00)83480-5.
9
Semi-micro method for liquid-chromatographic determination of cyclosporin A in whole blood with use of a rapid extraction procedure.采用快速萃取程序的全血中环孢素A的液相色谱半微量测定法。
Clin Chem. 1990 Jun;36(6):1253.
10
High pressure liquid chromatographic determination of cyclosporin-A in human plasma.
Res Commun Chem Pathol Pharmacol. 1982 Sep;37(3):431-44.

引用本文的文献

1
Effect of column temperature and eluent flow rate on the high performance liquid chromatographic analysis of cyclosporin a and d.柱温及洗脱液流速对环孢素 A 和 D 的高效液相色谱分析的影响。
Pharm Res. 1984 Nov;1(6):245-9. doi: 10.1023/A:1016337817145.
2
EFFECT OF CYCLOSPORIN ON HEPATIC REGENERATION.环孢素对肝再生的影响。
Surg Forum. 1986;37:352-354.
3
Hepatic Homograft Survival in Pediatric Orthotopic Liver Transplantation with Cyclosporine and Steroids.环孢素和类固醇用于小儿原位肝移植时肝同种异体移植物的存活情况
Transplant Proc. 1983 Dec 1;15(4, suppl 1):2592-2596.
4
Biliary Excretion of Cyclosporine in Liver Transplant Patients.肝移植患者中环孢素的胆汁排泄
Transplant Proc. 1985 Feb;17(1):286-289.
5
Cyclosporine G Analysis and Monitoring by High-Pressure Liquid Chromatography.环孢素G的高压液相色谱分析与监测
Transplant Proc. 1986 Aug;18(4):771-773.
6
Cyclosporine Monitoring and Pharmacokinetics in Pediatrie Liver Transplant Patients.小儿肝移植患者中环孢素的监测与药代动力学
Transplant Proc. 1985 Feb;17(1):1172-1175.
7
Clinical chemistry through Clinical Chemistry: a journal timeline.通过《临床化学》看临床化学：期刊发展历程
Clin Chem. 2004 Dec;50(12):2415-58. doi: 10.1373/clinchem.2004.042820.
8
Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin.用环孢素治疗相关原发性硬化性胆管炎后溃疡性结肠炎的疾病活动情况。
Gut. 1993 Feb;34(2):242-6. doi: 10.1136/gut.34.2.242.
9
Effect of cyclosporin A on glomerular filtration rate in children with minimal change nephrotic syndrome.环孢素A对微小病变型肾病综合征患儿肾小球滤过率的影响。
Pediatr Nephrol. 1994 Aug;8(4):404-7. doi: 10.1007/BF00856512.
10
Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat.环孢素A不影响生长中大鼠器官水平的皮质骨绝对吸收速率。
Calcif Tissue Int. 1994 Oct;55(4):295-301. doi: 10.1007/BF00310409.