Division of Institutional Review and Research Ethics, Nicholas Cardinal Cheong Graduate School for Life, The Catholic University of Korea, Seoul 06591, Korea.
Division of Institutional Review and Research Ethics, Nicholas Cardinal Cheong Graduate School for Life, The Catholic University of Korea, Seoul 06591, Korea; BIC Study, Seoul 06647, Korea.
BMB Rep. 2017 Dec;50(12):610-614. doi: 10.5483/bmbrep.2017.50.12.225.
Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on the available Three Rs resources is essential for both ethical and scientific reasons. Appropriate experimental design and statistical analysis techniques are particularly necessary for research involving the use of animals, because this can improve animal welfare and scientific outcomes, as well as saving animal lives. There are a number of resources to help researchers improve their search techniques, experimental design strategies, and their reporting of research involving the use of animals. However, there is little specific information or resources on the Three Rs alternatives that is readily available in the Korean language. This paper outlines the common errors made by submitting researchers that have been repeatedly observed during the ethical review of experimental protocols over the last ten years, and provides information on the Korean resources available to promote good scientific practice. This could help to bridge the gap between Korean scientists and animal welfare advocates assisting scientists to improve ethical considerations and conduct responsible research. [BMB Reports 2017; 50(12): 610-614].
计划进行动物实验研究的科学家必须对替代、减少或优化（即“3R”）的可能性进行评估，其研究方案必须经过机构动物护理和使用委员会审查。出于伦理和科学原因，良好的科学实践涉及对现有 3R 资源进行适当的搜索技术。由于这可以改善动物福利和科学成果，并拯救动物生命，因此，涉及动物使用的研究特别需要适当的实验设计和统计分析技术。有许多资源可以帮助研究人员提高他们的搜索技术、实验设计策略以及动物使用研究的报告。然而，在韩语中，很少有关于 3R 替代品的具体信息或资源。本文概述了提交研究人员在过去十年中进行的实验方案伦理审查中反复观察到的常见错误，并提供了有关促进良好科学实践的可用韩语资源的信息。这有助于弥合韩国科学家和动物福利倡导者之间的差距，帮助科学家改善伦理考虑并进行负责任的研究。[BMB 报告 2017；50(12)：610-614]。
