美国类风湿关节炎的特征与风险因素：一项美国国家健康与营养检查调查分析
Characteristics and risk factors of rheumatoid arthritis in the United States: an NHANES analysis.
作者信息
Xu Bei, Lin Jin
机构信息
Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
PeerJ. 2017 Nov 24;5:e4035. doi: 10.7717/peerj.4035. eCollection 2017.
BACKGROUND
We examined the United States National Health and Nutrition Examination Survey (NHANES) database to determine factors associated with rheumatoid arthritis (RA) in adults 20 to 55 years of age.
METHODS
NHANES data collected between 2007 and 2014, excluding the 2011-2012 period, were used. Subjects were divided into those with and without RA. Demographic, clinical, and lifestyle factors were compared between the groups.
RESULTS
After applying inclusion/exclusion criteria, 8,789 persons were included in the study (8,483 without RA, 306 with RA). Multivariable analysis indicated that advanced age (odds ratio [OR] = 1.09, 95% CI [1.07-1.11], < 0.001), regular smoking (OR = 2.19, 95% CI [1.49-3.21], < 0.001), diabetes (OR = 2.00, 95% CI [1.35-2.95], = 0.001), obesity (reference, normal or underweight; OR = 3.31, 95% CI [2.05-5.36], < 0.001), and osteoporosis (OR = 3.68, 95% CI [1.64-8.22], = 0.002) were positively associated with RA. Covered by health insurance (OR = 1.81, 95% CI [1.12-2.93], = 0.016) and living in poverty (OR = 2.96, 95% CI [1.88-4.65], < 0.001) were also associated with having RA. Mexican American, Hispanic white or other Hispanic ethnicity (reference, non-Hispanic white; OR = 0.54, 95% CI [0.31-0.96], = 0.036), appropriate sleep duration (about 6-11 h, OR = 0.46, 95% CI [0.32-0.65], < 0.001), and insufficient vitamin A intake (reference, recommended; OR = 0.70, 95% CI [0.50-0.98], = 0.036) were negatively associated with RA.
DISCUSSION
Some factors associated with RA are potentially modifiable.
背景
我们研究了美国国家健康与营养检查调查（NHANES）数据库，以确定20至55岁成年人中与类风湿性关节炎（RA）相关的因素。
方法
使用2007年至2014年期间收集的NHANES数据，但不包括2011 - 2012年期间的数据。受试者被分为患有RA和未患RA两组。对两组之间的人口统计学、临床和生活方式因素进行了比较。
结果
在应用纳入/排除标准后，8789人被纳入研究（8483人无RA，306人有RA）。多变量分析表明，高龄（优势比[OR]=1.09，95%置信区间[CI][1.07 - 1.11]，P<0.001）、经常吸烟（OR = 2.19，95% CI[1.49 - 3.21]，P<0.001）、糖尿病（OR = 2.00，95% CI[1.35 - 2.95]，P = 0.001）、肥胖（参照，正常或体重不足；OR = 3.31，95% CI[2.05 - 5.36]，P<0.001）和骨质疏松症（OR = 3.68，95% CI[1.64 - 8.22]，P = 0.002）与RA呈正相关。参加医疗保险（OR = 1.81，95% CI[1.12 - 2.93]，P = 0.016）和生活贫困（OR = 2.96，95% CI[1.88 - 4.65]，P<0.001）也与患有RA有关。墨西哥裔美国人、西班牙裔白人或其他西班牙裔种族（参照，非西班牙裔白人；OR = 0.54，95% CI[0.31 - 0.96]，P = 0.036）、适当的睡眠时间（约6 - 11小时，OR = 0.46，95% CI[0.32 - 0.65]，P<0.001）和维生素A摄入不足（参照，推荐摄入量；OR = 0.70，95% CI[0.50 - 0.98]，P = 0.036）与RA呈负相关。
讨论
一些与RA相关的因素可能是可改变的。
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